Linked Life Data

3121453

Source:http://linkedlifedata.com/resource/pubmed/id/3121453

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1988-2-24
pubmed:abstractText
An intravenous injection of heparin releases diamine oxidase (DAO) from villous tip enterocytes. In a previous study, we found that postheparin plasma DAO (PHD) values were significantly lower in patients with malabsorption syndrome and small bowel atrophy at jejunal biopsy than in normal subjects. In this study we performed the PHD test in 14 coeliac patients before and after three and six months of gluten free diet to show whether the enterocytes maturing processes induced by the diet joined with enhanced PHD values and to assess the clinical usefulness of this test. In all subjects jejunal biopsy carried out after six months showed a partial but consistent histological recovery. The clinical status, xylosuria and daily faecal fat excretion improved progressively and there was a significant increase (p less than 0.001) in mean PHD activity that reached the normal range after three months. After six months a further slight increase of the mean PHD value was recorded. These data indicate that PHD values rise together with the improved intestinal absorptive functions of coeliac patients on gluten free diet and that this test is a useful tool in monitoring recovery of the small bowel mucosa.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/3121453-14234675, http://linkedlifedata.com/resource/pubmed/commentcorrection/3121453-14481667, http://linkedlifedata.com/resource/pubmed/commentcorrection/3121453-3091435, http://linkedlifedata.com/resource/pubmed/commentcorrection/3121453-3102190, http://linkedlifedata.com/resource/pubmed/commentcorrection/3121453-413549, http://linkedlifedata.com/resource/pubmed/commentcorrection/3121453-5364449, http://linkedlifedata.com/resource/pubmed/commentcorrection/3121453-6406546, http://linkedlifedata.com/resource/pubmed/commentcorrection/3121453-6416024, http://linkedlifedata.com/resource/pubmed/commentcorrection/3121453-6432527, http://linkedlifedata.com/resource/pubmed/commentcorrection/3121453-6435979, http://linkedlifedata.com/resource/pubmed/commentcorrection/3121453-6772669
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0017-5749
pubmed:author
pubmed:issnType
Print
pubmed:volume
28 Suppl
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
131-4
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Postheparin plasma diamine oxidase increases in patients with coeliac disease during gluten free diet.
pubmed:affiliation
Cattedra di Malattie dell' Apparato Digerente, 2a Facoltà di Medicina, Napoli, Italy.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't