Linked Life Data

3121130

Source:http://linkedlifedata.com/resource/pubmed/id/3121130

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1988-2-10
pubmed:abstractText
The monoclonal antibody E/C8 was originally generated against chicken dorsal root ganglia. The antigen detected by E/C8, NAPA-73, is an intermediate filament-associated protein. NAPA-73 was shown to be one of the earliest neuronal markers to appear during development since it appears in some neuronal precursor cells of the peripheral nervous system during development. Using [3H]thymidine pulse-chase experiments combined with immunocytochemistry, it is shown that the dividing neuroblasts from 6-day-old embryonic chick brains do not express NAPA-73. Only neurons that have undergone their terminal cell division either in the embryo or in cell culture express the E/C8 immunoreactivity. We conclude that E/C8 is a marker for postmitotic neurons in chick brain. The contrast between our findings and previous reports identifying NAPA-73 as one of the earliest neuronal markers may reflect a difference between the central and peripheral nervous systems.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
22
pubmed:volume
421
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
186-93
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
The expression of the intermediate filament-associated protein (NAPA-73) is associated with the stage of terminal differentiation of chick brain neurons.
pubmed:affiliation
Mental Retardation Research Center, University of California, Los Angeles 90024.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.