Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2-3
|
| pubmed:dateCreated |
1988-1-7
|
| pubmed:abstractText |
Even though the development of the membrane abnormalities in sickle cell erythrocytes is due to the presence of a mutant gene product, sickle cell anaemia is in a sense a membrane disease. In particular, the presence of iron-containing breakdown products of haemoglobin in the sickle cell membranes provides a source of continued oxidative damage. An understanding of the primary causes of these membrane abnormalities may be useful in the development of effective therapies.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0001-5792
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
78
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
105-8
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:3120454-Anemia, Sickle Cell,
pubmed-meshheading:3120454-Erythrocyte Membrane,
pubmed-meshheading:3120454-Hemoglobins,
pubmed-meshheading:3120454-Humans,
pubmed-meshheading:3120454-Iron,
pubmed-meshheading:3120454-Lipid Peroxides,
pubmed-meshheading:3120454-Oxidation-Reduction,
pubmed-meshheading:3120454-Reference Values,
pubmed-meshheading:3120454-Sickle Cell Trait
|
| pubmed:year |
1987
|
| pubmed:articleTitle |
Role of membrane-bound haemoglobin products in oxidative damage in sickle cell membranes.
|
| pubmed:affiliation |
Department of Biochemistry, Royal Free Hospital School of Medicine, London, UK.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|