Linked Life Data

3120161

Source:http://linkedlifedata.com/resource/pubmed/id/3120161

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1988-1-12
pubmed:abstractText
Nonhuman primates have been shown to demonstrate behavioral and physiologic reactions to social separation that suggest symptoms of clinical depression. Although care must be taken in the use of animal models of psychopathology, it can be argued that in the case of certain affective disorders, including depression, nonhuman primate response to separation meets the criteria for validity. A variety of social, environmental, and genetic factors can influence the separation response in terms of intensity and specific types of symptomatology, and through the use of experimental manipulations, the relative importance of these and other variables in mediating depressive reactions have been studied. The effects of catecholamine depleting drugs (such as AMPT) as well as therapeutic agents on separation-induced depression in monkeys are being studied in an effort to determine underlying mechanisms of depression and particularly how neurochemical factors may interact synergistically with environmental and psychosocial factors in determining severity and nature of depressive reactions to separation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0193-953X
pubmed:author
pubmed:issnType
Print
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
437-47
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Primate models of separation-induced depression.
pubmed:affiliation
Department of Psychiatry, State University of New York, Brooklyn.
pubmed:publicationType
Journal Article, Review