Linked Life Data

3119025

Source:http://linkedlifedata.com/resource/pubmed/id/3119025

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6601
pubmed:dateCreated
1987-12-29
pubmed:abstractText
Considerable bone loss often occurs after menopause, particularly if menopause is induced by surgery. For perhaps two years bone formation fails to keep pace with the rapid acceleration of bone resorption that occurs after sex hormone withdrawal. The threat that this poses to the integrity of the skeleton is not clear. Because ethical constraints limit histological studies in normal women existing normal data and statistical modelling techniques were used to explore the dynamics of iliac trabecular bone after menopause. Trabeculae are breached during remodelling when the osteoclasts resorb to a depth equal to the trabecular thickness. Since holes in trabecular plates cannot normally be bridged such defects are probably permanent. Men lose 7% of their vertebral trabecular bone every 10 years; deeper than average resorption of trabeculae at the thin end of the normal range would account for it. The dramatic losses of trabecular bone that are seen in some postmenopausal women, however, require a period of imbalance between bone formation and bone resorption since this leads rapidly to generalised thinning. The statistical model suggested that an imbalance lasting only two years may account for eventual losses of up to half of the iliac trabecular bone. Further understanding is needed of what determines the amount of bone lost in the immediate postmenopause, which varies considerably among women. A simple mean is needed of identifying women who will lose bone most rapidly at the menopause. This must be suitable for use in general practice because these women should probably be offered long term hormone replacement treatment within a few months of the last menstruation.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/3119025-1000353, http://linkedlifedata.com/resource/pubmed/commentcorrection/3119025-2879090, http://linkedlifedata.com/resource/pubmed/commentcorrection/3119025-3621607, http://linkedlifedata.com/resource/pubmed/commentcorrection/3119025-3700651, http://linkedlifedata.com/resource/pubmed/commentcorrection/3119025-3789576, http://linkedlifedata.com/resource/pubmed/commentcorrection/3119025-6107766, http://linkedlifedata.com/resource/pubmed/commentcorrection/3119025-6291439, http://linkedlifedata.com/resource/pubmed/commentcorrection/3119025-6432170, http://linkedlifedata.com/resource/pubmed/commentcorrection/3119025-6630513, http://linkedlifedata.com/resource/pubmed/commentcorrection/3119025-6791782, http://linkedlifedata.com/resource/pubmed/commentcorrection/3119025-6977427, http://linkedlifedata.com/resource/pubmed/commentcorrection/3119025-7083776, http://linkedlifedata.com/resource/pubmed/commentcorrection/3119025-7313505, http://linkedlifedata.com/resource/pubmed/commentcorrection/3119025-737547, http://linkedlifedata.com/resource/pubmed/commentcorrection/3119025-739174, http://linkedlifedata.com/resource/pubmed/commentcorrection/3119025-7462421
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0267-0623
pubmed:author
pubmed:issnType
Print
pubmed:day
26
pubmed:volume
295
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
757-60
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Bone turnover and trabecular plate survival after artificial menopause.
pubmed:affiliation
Bone Disease Research Group, MRC Clinical Research Centre, Middlesex.
pubmed:publicationType
Journal Article