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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
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pubmed:dateCreated |
1987-12-21
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pubmed:abstractText |
Two bovine brain-derived growth factors, BDGF I and BDGF II, were isolated using the same extraction procedure as previously described for eye-derived growth factors (EDGF). The hypothesis that these growth factors were identical to EDGF I and EDGF II, respectively, was supported by their similar molecular weights (16,000 and 15,000, respectively) and isoelectric points (9.0 and 5.0, respectively), their identical retention behavior on reverse-phase chromatography and their similar amino acid compositions. From studies on their binding properties to cell surfaces, competition between EDGF I and BDGF I as well as competition between EDGF II and BDGF II to the same receptor was observed. The amino terminal sequence of EDGF II (1-16) was shown to be identical to the amino acid residues (7-22) of the acidic FGF, strongly confirming our observations on the identity of the factors isolated from bovine brain and retina.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0300-9084
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
69
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
511-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:3118966-Amino Acid Sequence,
pubmed-meshheading:3118966-Amino Acids,
pubmed-meshheading:3118966-Animals,
pubmed-meshheading:3118966-Binding, Competitive,
pubmed-meshheading:3118966-Brain Chemistry,
pubmed-meshheading:3118966-Cattle,
pubmed-meshheading:3118966-Chromatography,
pubmed-meshheading:3118966-Chromatography, High Pressure Liquid,
pubmed-meshheading:3118966-Electrophoresis, Polyacrylamide Gel,
pubmed-meshheading:3118966-Growth Substances,
pubmed-meshheading:3118966-Isoelectric Point,
pubmed-meshheading:3118966-Molecular Sequence Data,
pubmed-meshheading:3118966-Molecular Weight,
pubmed-meshheading:3118966-Radioligand Assay,
pubmed-meshheading:3118966-Retina
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pubmed:year |
1987
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pubmed:articleTitle |
Biochemical comparative studies between eye- and brain-derived growth factors.
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pubmed:affiliation |
Laboratoire de Biotechnologie des Cellules Eucaryotes, Université Paris Val-de-Marne, Créteil, France.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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