Linked Life Data

3118905

Source:http://linkedlifedata.com/resource/pubmed/id/3118905

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1988-1-4
pubmed:abstractText
The demonstration of effector functions of platelets in parasitic diseases raised the question of their possible regulation by T lymphocytes. Normal human platelets, treated with culture supernatants from antigen- or mitogen-stimulated CD4+/CD8- T cells, developed the capacity to kill young larvae of Schistosoma mansoni, in the absence of antibodies. The presence of IFN gamma in the lymphocyte supernatants, the neutralization by monoclonal anti-IFN gamma antibody, and the direct inducer effect of recombinant IFN gamma, clearly identify this lymphokine as one of the stimulator factors. In contrast, ConA- and antigen-stimulated human CD8+/CD4- T-cell supernatants contained a factor able to inhibit the IgE-dependent platelet cytotoxicity toward the same targets. The production of oxygen metabolites by IgE-coated platelets stimulated by anti-IgE was also strongly inhibited by this lymphokine. This platelet activity suppressive lymphokine (PASL) was identified as a polypeptide of 15 to 20 Kd with a pI of 4.6. The in vivo relevance of PASL was demonstrated by the complete abolition, after PASL treatment, of the protection normally conferred following a challenge infection by intravenous passive transfer of platelets from immune to normal rats.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0769-2625
pubmed:author
pubmed:issnType
Print
pubmed:volume
138
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
585-97
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:articleTitle
The effector function of platelets is induced and regulated by T lymphocytes.
pubmed:affiliation
CIBP, Unité Mixte INSERM 167, CNRS 624, Institut Pasteur, Lille, France.
pubmed:publicationType
Journal Article