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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4828
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pubmed:dateCreated |
1987-12-4
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pubmed:databankReference |
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M18508,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M18509,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M18510,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M18511,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M18512,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M18513,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M18514,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M18515,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M18516,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M18517,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M18518,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M18519,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M18520,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M18521,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M21553
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pubmed:abstractText |
Diversification of the antibody repertoire in mammals results from a series of apparently random somatically propagated gene rearrangement and mutational events. Nevertheless, it is well known that the adult repertoire of antibody specificities is acquired in a developmentally programmed fashion. As previously shown, rearrangement of the gene segments encoding the heavy-chain variable regions (VH) of mouse antibodies is also developmentally ordered: the number of VH gene segments rearranged in B lymphocytes of fetal mice is small but increased progressively after birth. In this report, human fetal B-lineage cells were also shown to rearrange a highly restricted set of VH gene segments. In a sample of heavy-chain transcripts from a 130-day human fetus the most frequently expressed human VH element proved to be closely related to the VH element most frequently expressed in murine fetal B-lineage cells. These observations are important in understanding the development of immunocompetence.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
6
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pubmed:volume |
238
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
791-3
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:3118465-Adult,
pubmed-meshheading:3118465-Amino Acid Sequence,
pubmed-meshheading:3118465-Animals,
pubmed-meshheading:3118465-B-Lymphocytes,
pubmed-meshheading:3118465-Base Sequence,
pubmed-meshheading:3118465-Fetus,
pubmed-meshheading:3118465-Genes, Immunoglobulin,
pubmed-meshheading:3118465-Humans,
pubmed-meshheading:3118465-Immunoglobulin Heavy Chains,
pubmed-meshheading:3118465-Immunoglobulin Variable Region,
pubmed-meshheading:3118465-Mice,
pubmed-meshheading:3118465-Molecular Sequence Data,
pubmed-meshheading:3118465-Mutation,
pubmed-meshheading:3118465-Sequence Homology, Nucleic Acid
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pubmed:year |
1987
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pubmed:articleTitle |
Early restriction of the human antibody repertoire.
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pubmed:affiliation |
Howard Hughes Medical Institute, University of Washington, Seattle 98195.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
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