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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1987-12-1
|
| pubmed:abstractText |
The spontaneous chemiluminescence activity (CL-A) of peripheral mononuclear cells (MNC) was examined in Lewis rats with acute experimental allergic encephalomyelitis (EAE), compared to rats immunized with complete adjuvant (n = 11) and healthy animals (n = 16). In rats with EAE, CL-A increased sharply 8-9 days after immunization (3420 +/- 3124 counts/10 s, n = 16) at the time of flattening of the weight curve. This CL-A peak was compared to that of animals immunized with complete adjuvant: 765 +/- 441 counts/10 s (P = 0.01) and healthy rats: 450 +/- 172 counts/10 s (P = 0.0001). After this initial peak in EAE rats, CL-A decreased almost to normal values when animals lost weight (746 +/- 251 counts, n = 19) and tail paralysis developed (557 +/- 251 counts/10 s, n = 15). CL-A increased again with the onset of paralysis of the extremities (1527 +/- 990 counts/10 s, n = 11), followed by a decrease as the clinical course deteriorated. Finally, CL-A approached normal values as the animals improved. A significant increase in the number of meningeal (P less than 0.01) and perivascular (P less than 0.01) cells in the CNS coincided with the initial CL-A peak. Gel filtration of the serum of rats with increased CL-A revealed at least one substance, with a molecular weight between 13,700 and 43,000 Da, which stimulated the CL-A of normal mononuclear cells.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0165-5728
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
16
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
307-16
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:3117847-Acute Disease,
pubmed-meshheading:3117847-Animals,
pubmed-meshheading:3117847-Brain,
pubmed-meshheading:3117847-Encephalomyelitis, Autoimmune, Experimental,
pubmed-meshheading:3117847-Interferon-gamma,
pubmed-meshheading:3117847-Leukocytes, Mononuclear,
pubmed-meshheading:3117847-Luminescent Measurements,
pubmed-meshheading:3117847-Lymphocytes,
pubmed-meshheading:3117847-Male,
pubmed-meshheading:3117847-Rats,
pubmed-meshheading:3117847-Rats, Inbred Lew
|
| pubmed:year |
1987
|
| pubmed:articleTitle |
The chemiluminescence activity of peripheral blood mononuclear cells during acute experimental allergic encephalomyelitis.
|
| pubmed:affiliation |
Department of Neurology, Johannes Gutenberg University, Mainz, F.R.G.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|