| pubmed-article:3117059 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3117059 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:3117059 | lifeskim:mentions | umls-concept:C0042071 | lld:lifeskim |
| pubmed-article:3117059 | lifeskim:mentions | umls-concept:C0027950 | lld:lifeskim |
| pubmed-article:3117059 | lifeskim:mentions | umls-concept:C0008018 | lld:lifeskim |
| pubmed-article:3117059 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:3117059 | pubmed:dateCreated | 1987-11-12 | lld:pubmed |
| pubmed-article:3117059 | pubmed:abstractText | Human purified urokinase-type plasminogen activator (u-PA) stimulates chemoattractant activity for human neutrophils using modified Boyden chambers. Checkerboard analysis performed by adding different concentrations of u-PA above and below the polycarbonate filters revealed maximum migration required a positive concentration gradient. These results suggest that uPA was in fact stimulating neutrophil chemotaxis. Incubation of u-PA with an anti-u-PA goat antibody completely abolished the chemotactic activity of u-PA while incubation with the serine protease inhibitor, diisopropyl fluorophosphate, did not reduce chemotactic activity. Purified human tissue-type plasminogen activator demonstrated no chemotactic activity for human neutrophils when tested at concentrations similar to u-PA. These results suggests that the expression of chemotactic activity of u-PA may serve to recruit circulating leukocytes to the inflammatory site. | lld:pubmed |
| pubmed-article:3117059 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3117059 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3117059 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3117059 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3117059 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3117059 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3117059 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3117059 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3117059 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:3117059 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:3117059 | pubmed:author | pubmed-author:GudewiczP WPW | lld:pubmed |
| pubmed-article:3117059 | pubmed:author | pubmed-author:GilboaNN | lld:pubmed |
| pubmed-article:3117059 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3117059 | pubmed:day | 30 | lld:pubmed |
| pubmed-article:3117059 | pubmed:volume | 147 | lld:pubmed |
| pubmed-article:3117059 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3117059 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3117059 | pubmed:pagination | 1176-81 | lld:pubmed |
| pubmed-article:3117059 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:3117059 | pubmed:meshHeading | pubmed-meshheading:3117059-... | lld:pubmed |
| pubmed-article:3117059 | pubmed:meshHeading | pubmed-meshheading:3117059-... | lld:pubmed |
| pubmed-article:3117059 | pubmed:meshHeading | pubmed-meshheading:3117059-... | lld:pubmed |
| pubmed-article:3117059 | pubmed:meshHeading | pubmed-meshheading:3117059-... | lld:pubmed |
| pubmed-article:3117059 | pubmed:meshHeading | pubmed-meshheading:3117059-... | lld:pubmed |
| pubmed-article:3117059 | pubmed:meshHeading | pubmed-meshheading:3117059-... | lld:pubmed |
| pubmed-article:3117059 | pubmed:meshHeading | pubmed-meshheading:3117059-... | lld:pubmed |
| pubmed-article:3117059 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:3117059 | pubmed:articleTitle | Human urokinase-type plasminogen activator stimulates chemotaxis of human neutrophils. | lld:pubmed |
| pubmed-article:3117059 | pubmed:affiliation | Department of Physiology, Albany Medical College, NY 12208. | lld:pubmed |
| pubmed-article:3117059 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3117059 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:3117059 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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