rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
3
|
pubmed:dateCreated |
1987-11-2
|
pubmed:abstractText |
A 66-year-old man with the lupus anticoagulant-hypoprothrombinemia syndrome was treated with cyclophosphamide and prednisone to correct a factor II deficiency prior to elective major surgery. Whereas the lupus anticoagulant activity persisted, functional factor II levels normalized and he underwent surgery without a bleeding diathesis. Immunosuppressive therapy may temporarily normalize factor II levels in patients with the lupus anticoagulant-hypoprothrombinemia syndrome and reduce the risk of excessive hemorrhage. The disparate response of the lupus anticoagulant and hypoprothrombinemia to immunosuppression suggests that the lupus anticoagulant did not directly cause the hypoprothrombinemia.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
AIM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Sep
|
pubmed:issn |
0002-9343
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
83
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
563-6
|
pubmed:dateRevised |
2004-11-17
|
pubmed:meshHeading |
pubmed-meshheading:3116849-Aged,
pubmed-meshheading:3116849-Autoantibodies,
pubmed-meshheading:3116849-Blood Coagulation Factors,
pubmed-meshheading:3116849-Cyclophosphamide,
pubmed-meshheading:3116849-Hemorrhagic Disorders,
pubmed-meshheading:3116849-Humans,
pubmed-meshheading:3116849-Hypoprothrombinemias,
pubmed-meshheading:3116849-Immunosuppressive Agents,
pubmed-meshheading:3116849-Lupus Coagulation Inhibitor,
pubmed-meshheading:3116849-Male,
pubmed-meshheading:3116849-Postoperative Complications,
pubmed-meshheading:3116849-Prednisone,
pubmed-meshheading:3116849-Preoperative Care,
pubmed-meshheading:3116849-Risk Factors,
pubmed-meshheading:3116849-Syndrome
|
pubmed:year |
1987
|
pubmed:articleTitle |
Correction of hypoprothrombinemia by immunosuppressive treatment of the lupus anticoagulant-hypoprothrombinemia syndrome.
|
pubmed:affiliation |
Division of Hematology-Oncology, Durham Veterans Administration Medical Center, North Carolina 27705.
|
pubmed:publicationType |
Journal Article,
Case Reports
|