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rdf:type |
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|
lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
1987-11-6
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pubmed:abstractText |
A select number of 1-formyl- and 1-thioformyl-2-methylaziridine derivatives and the corresponding 1a-substituted mitomycin C analogues were synthesized and tested for antineoplastic activity by using an in vivo test with murine P388 leukemia. Select compounds were also tested in vivo with murine melanoma B16. Several of the mitomycin C derivatives displayed activity and some of the mitomycin C analogues were comparable in activity to the parent compound.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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|
pubmed:month |
Oct
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pubmed:issn |
0022-2623
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
30
|
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pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
1767-73
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
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pubmed:year |
1987
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pubmed:articleTitle |
Synthesis and antineoplastic activity of 1a-formyl and 1a-thioformyl derivatives of mitomycin C and 2-methylaziridine.
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pubmed:affiliation |
Department of Chemistry, University of Houston, Texas 77004.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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