Linked Life Data

3116124

Source:http://linkedlifedata.com/resource/pubmed/id/3116124

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1987-11-3
pubmed:abstractText
Thirteen dogs were entered into a pilot study to assess the toxicities associated with polyamine biosynthetic enzyme inhibitors as heat sensitizing drugs and whole body hyperthermia either alone or in combination. Disease-free and tumour-bearing animals were entered in an effort to assess the response of canine lymphoproliferative disorders as well. Conclusions reached were as follows. (1) A large tumour burden precludes treatment. (2) Liver involvement and decreased platelet numbers would appear to offer a grave prognosis for survival and should be assessed closely in determining eligibility. (3) Polyamine biosynthetic enzyme inhibitors and whole body hyperthermia appear to be tumoricidal alone or in combination, although less effective and with greater toxicities than accepted chemotherapeutic regimens. (4) Heat sensitization in vivo has not yet been demonstrated.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0265-6736
pubmed:author
pubmed:issnType
Print
pubmed:volume
3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
187-98
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:articleTitle
Whole body hyperthermia and heat-sensitizing drugs: a pilot study in canine lymphoproliferative disease.
pubmed:affiliation
Department of Radiation Oncology, University of Arizona, Tucson 85724.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S.