|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
8
|
|
pubmed:dateCreated |
1987-11-9
|
|
pubmed:abstractText |
Stimulation of rat astrocytes in vitro by calcium ionophore A23187 and/or lipopolysaccharide results in the generation of a cytotoxic factor that is functionally similar to the previously described macrophage-derived cytotoxic factor, tumor necrosis factor. Like the macrophage product, the astrocyte cytotoxic factor kills murine L 929 cell targets. In addition, it kills rat oligodendrocytes, the myelin-producing cells of the central nervous system. Human recombinant tumor necrosis factor also has cytotoxic activity directed against rat oligodendrocytes.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Oct
|
|
pubmed:issn |
0022-1767
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
15
|
|
pubmed:volume |
139
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
2593-7
|
|
pubmed:dateRevised |
2007-11-14
|
|
pubmed:meshHeading |
pubmed-meshheading:3116087-Animals,
pubmed-meshheading:3116087-Astrocytes,
pubmed-meshheading:3116087-Calcimycin,
pubmed-meshheading:3116087-Cytotoxins,
pubmed-meshheading:3116087-Demyelinating Diseases,
pubmed-meshheading:3116087-Inflammation,
pubmed-meshheading:3116087-Lipopolysaccharides,
pubmed-meshheading:3116087-Neuroglia,
pubmed-meshheading:3116087-Oligodendroglia,
pubmed-meshheading:3116087-Rabbits,
pubmed-meshheading:3116087-Rats,
pubmed-meshheading:3116087-Recombinant Proteins,
pubmed-meshheading:3116087-Tumor Necrosis Factor-alpha
|
|
pubmed:year |
1987
|
|
pubmed:articleTitle |
Production of cytotoxic factor for oligodendrocytes by stimulated astrocytes.
|
|
pubmed:affiliation |
Department of Pathology, University of Maryland School of Medicine, Baltimore 21201.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
