Linked Life Data

3115993

Source:http://linkedlifedata.com/resource/pubmed/id/3115993

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1987-11-10
pubmed:abstractText
1 Denervation was induced in dogs by 6-hydroxydopamine (6-OHDA) treatment. The effects of this on cell nucleus activity of smooth muscle cells and fibroblasts of the mesenteric artery (main trunk and jejunal branches) and of myocardial cells, fibroblasts and endothelial capillary cells of the heart were studied. 2 Changes in the nucleii or cell size measured with light microscopy morphometric techniques and frequency of nucleoli in myocardial cells were chosen as indices of cell nucleus activity state. 3 Noradrenaline depletion 5 days after initiation of 6-OHDA administration was much more marked in the heart (with a content of 10% of control values) than in the arterial vessels (with a content of 50% of control values). 4 Denervation by 6-OHDA led to an increase in the synthetic activity state of the cell nucleus in all cell types and tissues. 5 Plasma noradrenaline and adrenaline levels were strikingly increased by 6-OHDA treatment. 6 The results strongly support the hypothesis of a nuclear modulating effect of the sympathetic innervation upon the effector cells. The incapacity of high noradrenaline plasma levels to prevent the consequences of sympathetic denervation on the effector cells appears to indicate that in the sympathetic innervation there is a 'trophic factor' which is not identical with noradrenaline.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0144-1795
pubmed:author
pubmed:issnType
Print
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
119-26
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Effects of denervation induced by 6-hydroxydopamine on cell nucleus activity of arterial and cardiac cells of the dog.
pubmed:affiliation
Laboratório de Farmacologia, Faculdade de Medicina, Porto, Portugal.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't