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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1987-11-3
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pubmed:abstractText |
PHA activated human peripheral blood mononuclear cells (MNC) were incubated with human interleukin 2 (IL-2) in the absence or in the presence of 10(-6)-10(-9) M hydrocortisone (HC). HC suppressed the proliferative response of the activated MNC to highly purified human leucocyte IL-2 in a dose dependent manner. This suppression was in full accordance with an inhibition of the IL-2 binding capacity, whereby the high affinity binding sites were reduced by 85%, while the low affinity sites were less affected. The mechanism by which HC inhibits the binding of IL-2 is still unknown. Evidence is presented that HC binds only weakly to IL-2. We conclude that HC interferes with the IL-2 binding by modulating the binding and/or signal processing function of the IL-2 receptor.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3115640-301151,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3115640-314468,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3115640-3875418,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3115640-3907369,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3115640-3936657,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3115640-4808638,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3115640-5114047,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3115640-6090574,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3115640-6214495,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3115640-6413637,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3115640-6429853,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3115640-6602847,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3115640-6965362,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3115640-6975347,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3115640-7264103,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3115640-769625
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0009-9104
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
68
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
156-61
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3115640-Binding, Competitive,
pubmed-meshheading:3115640-Cell Division,
pubmed-meshheading:3115640-Humans,
pubmed-meshheading:3115640-Hydrocortisone,
pubmed-meshheading:3115640-Interleukin-2,
pubmed-meshheading:3115640-Leukocytes,
pubmed-meshheading:3115640-Lymphocyte Activation,
pubmed-meshheading:3115640-Phytohemagglutinins,
pubmed-meshheading:3115640-Receptors, Immunologic,
pubmed-meshheading:3115640-Receptors, Interleukin-2,
pubmed-meshheading:3115640-T-Lymphocytes
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pubmed:year |
1987
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pubmed:articleTitle |
Corticosteroid-interleukin 2 interactions: inhibition of binding of interleukin 2 to interleukin 2 receptors.
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pubmed:affiliation |
Forschungsinstitut Borstel, FRG.
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pubmed:publicationType |
Journal Article
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