Linked Life Data

3115273

Source:http://linkedlifedata.com/resource/pubmed/id/3115273

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
1987-9-28
pubmed:abstractText
Recent study of the expression of monocyte differentiation antigens (MAg) and HLA-DR on peripheral blood monocytes (PBM) has led to the recognition of resting and activated monocyte phenotypes. The former is identified by the expression of large amounts of MAg (i.e., Mo2 and 63D3) and small amounts of HLA-DR, while the latter is identified by the reverse. We studied the phenotypes of PBM and synovial fluid monocytes (SFM) of patients with chronic inflammatory arthritis and found that PBM were primarily resting and SFM were usually activated. In addition, we measured the degree of modulation of MAg and HLA-DR by gamma-interferon (gamma-IFN). Patient PBM reacted the same as PBM from normal individuals (i.e., MAg decreased and HLA-DR increased after exposure to gamma-IFN). However, in patient SFM, HLA-DR did not increase with exposure to gamma-IFN because expression was already maximal. Interestingly, MAg could still be down-regulated on gamma-IFN-treated SFM, even when expression began at a very low level (i.e., activated phenotype). This independent regulation of MAg and HLA-DR suggests that macrophage activating factors other than gamma-IFN may be responsible, in part, for the activated phenotypes observed.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0004-3591
pubmed:author
pubmed:issnType
Print
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
857-63
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Peripheral blood and synovial fluid monocyte activation in inflammatory arthritis. I. A cytofluorographic study of monocyte differentiation antigens and class II antigens and their regulation by gamma-interferon.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't