Linked Life Data

3115256

Source:http://linkedlifedata.com/resource/pubmed/id/3115256

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1987-10-14
pubmed:abstractText
An animal system is described that allows the analysis of the interaction of persisting hamster papovavirus (HaPV) genomes with the tumor-promoting phorbol ester TPA. In a colony of HaPV-bearing Syrian golden hamsters, extrachromosomal HaPV genomes were detected by Southern blot hybridization in DNA isolated from skin biopsies. Chronic topical treatment of hamsters with TPA resulted in a dramatic increase of viral DNA in skin cells at the site of TPA application. After finishing the TPA treatment, the amount of extrachromosomal viral DNA declined but was still enhanced more than three months thereafter. This model offers the possibility of investigating, at the molecular level, the initiating role of virus in tumorigenesis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0232-766X
pubmed:author
pubmed:issnType
Print
pubmed:volume
46
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
K1-7
pubmed:dateRevised
2005-11-17
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
A novel system for studying in vivo effects of tumor promoters on DNA tumor viruses.
pubmed:publicationType
Journal Article