pubmed-article:3114404 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:3114404 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
pubmed-article:3114404 | lifeskim:mentions | umls-concept:C0020676 | lld:lifeskim |
pubmed-article:3114404 | lifeskim:mentions | umls-concept:C0205102 | lld:lifeskim |
pubmed-article:3114404 | lifeskim:mentions | umls-concept:C0040162 | lld:lifeskim |
pubmed-article:3114404 | lifeskim:mentions | umls-concept:C0040160 | lld:lifeskim |
pubmed-article:3114404 | lifeskim:mentions | umls-concept:C0040165 | lld:lifeskim |
pubmed-article:3114404 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
pubmed-article:3114404 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
pubmed-article:3114404 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
pubmed-article:3114404 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
pubmed-article:3114404 | lifeskim:mentions | umls-concept:C0332152 | lld:lifeskim |
pubmed-article:3114404 | lifeskim:mentions | umls-concept:C0022028 | lld:lifeskim |
pubmed-article:3114404 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
pubmed-article:3114404 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
pubmed-article:3114404 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
pubmed-article:3114404 | lifeskim:mentions | umls-concept:C0332293 | lld:lifeskim |
pubmed-article:3114404 | lifeskim:mentions | umls-concept:C0439836 | lld:lifeskim |
pubmed-article:3114404 | lifeskim:mentions | umls-concept:C0205460 | lld:lifeskim |
pubmed-article:3114404 | lifeskim:mentions | umls-concept:C0332120 | lld:lifeskim |
pubmed-article:3114404 | pubmed:issue | 3 | lld:pubmed |
pubmed-article:3114404 | pubmed:dateCreated | 1987-10-13 | lld:pubmed |
pubmed-article:3114404 | pubmed:abstractText | The effects of a physiological replacement dose of thyroxine (T4) on the response of plasma TSH to TRH in hypothyroid rats were studied. Animals were treated with iopanoic acid (IOP; 5 mg/100 g body weight) or vehicle 24, 12 and 1.5 h before the experiment. Thereafter, 800 ng T4/100 g body weight were administered i.v. and 20 min later 1 microgram TRH/100 g body weight was injected i.v. In control rats the basal concentration of TSH was 1450 +/- 300 (S.E.M.) mu./1. The plasma concentration of TSH 10 min after injection of TRH increased to 167 +/- 14% of the mean basal value (P less than 0.001). The injection of T4 significantly (P less than 0.005) reduced the TSH response to TRH in both IOP-treated (118 +/- 15%) and vehicle-treated (108 +/- 15%) rats compared with untreated controls. Tri-iodothyronine (T3) was undetectable in the plasma of all rats, whereas the plasma concentration of T4 was 121 +/- 19 nmol/l in IOP-treated and 139 +/- 23 nmol/l in vehicle-treated rats 30 min after injection of 800 ng T4/100 g body weight. In pituitary cells of control rats, cytoplasmic radioactivity 30 min after injection of [125I]T4 was 1.28 +/- 0.13 X 10(-2)% (76 +/- 6% T4 and 17 +/- 3% T3), whereas that in nuclei reached 0.42 +/- 0.36 X 10(-2)% (51 +/- 4% T4 and 28 +/- 3% T3) of the injected dose.(ABSTRACT TRUNCATED AT 250 WORDS) | lld:pubmed |
pubmed-article:3114404 | pubmed:language | eng | lld:pubmed |
pubmed-article:3114404 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:3114404 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:3114404 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:3114404 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:3114404 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:3114404 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:3114404 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:3114404 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:3114404 | pubmed:month | Jun | lld:pubmed |
pubmed-article:3114404 | pubmed:issn | 0022-0795 | lld:pubmed |
pubmed-article:3114404 | pubmed:author | pubmed-author:ZaninovichA... | lld:pubmed |
pubmed-article:3114404 | pubmed:author | pubmed-author:BoadoR JRJ | lld:pubmed |
pubmed-article:3114404 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:3114404 | pubmed:volume | 113 | lld:pubmed |
pubmed-article:3114404 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:3114404 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:3114404 | pubmed:pagination | 349-54 | lld:pubmed |
pubmed-article:3114404 | pubmed:dateRevised | 2005-11-17 | lld:pubmed |
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pubmed-article:3114404 | pubmed:year | 1987 | lld:pubmed |
pubmed-article:3114404 | pubmed:articleTitle | Inhibition of the response of thyrotrophin to thyrotrophin-releasing hormone by thyroxine in hypothyroid rats treated with iopanoic acid: evidence suggesting an intrinsic biological activity of thyroxine without prior conversion to 3,5,3'-tri-iodothyronine. | lld:pubmed |
pubmed-article:3114404 | pubmed:publicationType | Journal Article | lld:pubmed |