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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions |
umls-concept:C0020676,
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0022028,
umls-concept:C0034693,
umls-concept:C0040160,
umls-concept:C0040162,
umls-concept:C0040165,
umls-concept:C0205102,
umls-concept:C0205460,
umls-concept:C0332120,
umls-concept:C0332152,
umls-concept:C0332293,
umls-concept:C0439836,
umls-concept:C0441655,
umls-concept:C0871261,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2911692
|
| pubmed:issue |
3
|
| pubmed:dateCreated |
1987-10-13
|
| pubmed:abstractText |
The effects of a physiological replacement dose of thyroxine (T4) on the response of plasma TSH to TRH in hypothyroid rats were studied. Animals were treated with iopanoic acid (IOP; 5 mg/100 g body weight) or vehicle 24, 12 and 1.5 h before the experiment. Thereafter, 800 ng T4/100 g body weight were administered i.v. and 20 min later 1 microgram TRH/100 g body weight was injected i.v. In control rats the basal concentration of TSH was 1450 +/- 300 (S.E.M.) mu./1. The plasma concentration of TSH 10 min after injection of TRH increased to 167 +/- 14% of the mean basal value (P less than 0.001). The injection of T4 significantly (P less than 0.005) reduced the TSH response to TRH in both IOP-treated (118 +/- 15%) and vehicle-treated (108 +/- 15%) rats compared with untreated controls. Tri-iodothyronine (T3) was undetectable in the plasma of all rats, whereas the plasma concentration of T4 was 121 +/- 19 nmol/l in IOP-treated and 139 +/- 23 nmol/l in vehicle-treated rats 30 min after injection of 800 ng T4/100 g body weight. In pituitary cells of control rats, cytoplasmic radioactivity 30 min after injection of [125I]T4 was 1.28 +/- 0.13 X 10(-2)% (76 +/- 6% T4 and 17 +/- 3% T3), whereas that in nuclei reached 0.42 +/- 0.36 X 10(-2)% (51 +/- 4% T4 and 28 +/- 3% T3) of the injected dose.(ABSTRACT TRUNCATED AT 250 WORDS)
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Iopanoic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Thyrotropin,
http://linkedlifedata.com/resource/pubmed/chemical/Thyrotropin-Releasing Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/Thyroxine,
http://linkedlifedata.com/resource/pubmed/chemical/Triiodothyronine
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0022-0795
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
113
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
349-54
|
| pubmed:dateRevised |
2005-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:3114404-Animals,
pubmed-meshheading:3114404-Cell Nucleus,
pubmed-meshheading:3114404-Cytoplasm,
pubmed-meshheading:3114404-Iopanoic Acid,
pubmed-meshheading:3114404-Male,
pubmed-meshheading:3114404-Pituitary Gland,
pubmed-meshheading:3114404-Rats,
pubmed-meshheading:3114404-Rats, Inbred Strains,
pubmed-meshheading:3114404-Thyroid Gland,
pubmed-meshheading:3114404-Thyrotropin,
pubmed-meshheading:3114404-Thyrotropin-Releasing Hormone,
pubmed-meshheading:3114404-Thyroxine,
pubmed-meshheading:3114404-Time Factors,
pubmed-meshheading:3114404-Triiodothyronine
|
| pubmed:year |
1987
|
| pubmed:articleTitle |
Inhibition of the response of thyrotrophin to thyrotrophin-releasing hormone by thyroxine in hypothyroid rats treated with iopanoic acid: evidence suggesting an intrinsic biological activity of thyroxine without prior conversion to 3,5,3'-tri-iodothyronine.
|
| pubmed:publicationType |
Journal Article
|