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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
1987-9-30
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pubmed:abstractText |
The resistance of mice against Mycobacterium tuberculosis infection after selective in vivo depletion of L3T4+ and Lyt-2+ T cells was studied. Thymectomized mice were treated with rat monoclonal antibodies against the L3T4 or Lyt-2 molecule to selectively eliminate the respective T-cell subset. In both L3T4+ and Lyt-2+ T-cell-depleted mice, resistance against subsequent infection with M. tuberculosis was markedly impaired compared with that in untreated controls, with L3T4+ T-cell-depleted mice showing more pronounced effects. Simultaneous depletion of L3T4+ and Lyt-2+ T cells did not further exacerbate infection. These findings suggest that both L3T4+ and Lyt-2+ T cells are involved in the acquisition of resistance against tuberculosis.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3114143-117073,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3114143-2943668,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3114143-2952852,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3114143-300350,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3114143-3083221,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3114143-3086874,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3114143-3088201,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3114143-3095237,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3114143-3097148,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3114143-3489772,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3114143-3512763,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3114143-3894232,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3114143-3900672,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3114143-3920148,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3114143-6150440,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3114143-6156984,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3114143-6176667,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3114143-6216407,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3114143-6418400,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3114143-6421492,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3114143-6602296,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3114143-6805064,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3114143-829904,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3114143-92183
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0019-9567
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
55
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2037-41
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3114143-Animals,
pubmed-meshheading:3114143-Antibodies, Monoclonal,
pubmed-meshheading:3114143-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:3114143-Antigens, Ly,
pubmed-meshheading:3114143-Antigens, Surface,
pubmed-meshheading:3114143-Cytotoxicity, Immunologic,
pubmed-meshheading:3114143-Immunity, Cellular,
pubmed-meshheading:3114143-Male,
pubmed-meshheading:3114143-Mice,
pubmed-meshheading:3114143-Mice, Inbred Strains,
pubmed-meshheading:3114143-Mycobacterium tuberculosis,
pubmed-meshheading:3114143-T-Lymphocytes,
pubmed-meshheading:3114143-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:3114143-Thymectomy,
pubmed-meshheading:3114143-Tuberculosis
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pubmed:year |
1987
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pubmed:articleTitle |
Impaired resistance to Mycobacterium tuberculosis infection after selective in vivo depletion of L3T4+ and Lyt-2+ T cells.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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