Linked Life Data

3112659

Source:http://linkedlifedata.com/resource/pubmed/id/3112659

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1987-9-1
pubmed:abstractText
Immunolabelling was performed on brain sections of scrapie-infected mice with antibodies against tau, a microtubule-associated protein, and against the paired helical filaments of Alzheimer's disease. Both kinds of antibodies have been shown previously to label paired helical filaments in neurons and in abnormal neurites associated with the senile plaques of Alzheimer's disease. Amyloid plaques in murine scrapie were labelled by both antisera. The structural substrate for the immunolabelling was probably the dystrophic neurites in the periphery of the plaques, leaving the amyloid core unstained. These results emphasize that similar mechanisms are likely to be involved in the pathogenesis of plaques in both diseases.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0304-3940
pubmed:author
pubmed:issnType
Print
pubmed:day
9
pubmed:volume
78
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
113-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Amyloid scrapie plaques in mice, and Alzheimer senile plaques, share common antigens with tau, a microtubule-associated protein.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't