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rdf:type |
|
|
lifeskim:mentions |
|
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pubmed:issue |
2
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pubmed:dateCreated |
1987-7-29
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|
pubmed:abstractText |
We found that tau, one of the major microtubule-associated proteins, is a good substrate for protein kinase C. The phosphorylation occurred mainly on serine residues and the sites phosphorylated by protein kinase C were largely different from those phosphorylated by cAMP-dependent protein kinase as analyzed by phosphopeptide mapping. The protein kinase C-mediated phosphorylation of tau reduced its abilities to promote tubulin polymerization and to cross-link actin filaments. The reduction in its abilities was in proportion to the number of phosphates incorporated into tau.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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|
pubmed:month |
Jun
|
|
pubmed:issn |
0014-5793
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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|
pubmed:day |
15
|
|
pubmed:volume |
217
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
237-41
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:3109941-Actins,
pubmed-meshheading:3109941-Animals,
pubmed-meshheading:3109941-Microtubule-Associated Proteins,
pubmed-meshheading:3109941-Microtubules,
pubmed-meshheading:3109941-Peptide Mapping,
pubmed-meshheading:3109941-Phosphorylation,
pubmed-meshheading:3109941-Phosphoserine,
pubmed-meshheading:3109941-Protein Kinase C,
pubmed-meshheading:3109941-Rabbits,
pubmed-meshheading:3109941-Tubulin,
pubmed-meshheading:3109941-tau Proteins
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pubmed:year |
1987
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|
pubmed:articleTitle |
Protein kinase C phosphorylates tau and induces its functional alterations.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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