Linked Life Data

3108691

Source:http://linkedlifedata.com/resource/pubmed/id/3108691

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1987-6-29
pubmed:abstractText
The effect of dopamine (DA) on growth hormone (GH) release was studied in perifused freshly dispersed rat anterior pituitary cells. Pulses of DA (0.01-100 nmol/l), each applied for 30 min, resulted in a prompt rise in GH release. This effect was reversible, concentration-dependent and partially antagonized by metoclopramide, a DA antagonist. The effect of DA was further tested on GH-stimulated secretion by human GH-releasing factor (hGRF). Perifusion with hGRF (6.25 pmol/l) for 2 min elicited an immediate rapid increase in GH release which lasted 20 min. Pretreatment of cells with DA (100 nmol/l) for 10 min and a subsequent hGRF challenge during continuation of DA perifusion significantly reduced the effect of hGRF pulses on GH release. The present data suggest that DA has direct opposite actions at the somatotroph level, stimulating the basal GH release and inhibiting the hGRF-induced GH secretion, and may thus be an important modulator of GH release.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0028-3835
pubmed:author
pubmed:issnType
Print
pubmed:volume
45
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
363-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Dual action of dopamine on growth hormone release in vitro.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't