| pubmed-article:3108142 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3108142 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:3108142 | lifeskim:mentions | umls-concept:C0039195 | lld:lifeskim |
| pubmed-article:3108142 | lifeskim:mentions | umls-concept:C0010592 | lld:lifeskim |
| pubmed-article:3108142 | lifeskim:mentions | umls-concept:C0376249 | lld:lifeskim |
| pubmed-article:3108142 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:3108142 | lifeskim:mentions | umls-concept:C1709634 | lld:lifeskim |
| pubmed-article:3108142 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:3108142 | pubmed:dateCreated | 1987-7-17 | lld:pubmed |
| pubmed-article:3108142 | pubmed:abstractText | A limiting dilution (LD) culture system was used to investigate the effect of cyclosporin A (CsA) on the activation and differentiation of human alloreactive cytotoxic T-lymphocyte precursors (CTL-p). CsA reduced in a dose-dependent fashion the frequency of alloantigen-inducible CTL-p. With most normal individuals tested there was a 20- to 50-fold reduction of alloreactive CTL-p frequencies in the presence of 500-1000 ng/ml CsA. Both unseparated T cells and CD8+ T cells were CsA-sensitive under LD culture conditions. Importantly, however, alloreactive CTL-p from two out of 21 normal individuals were found to be largely CsA-resistant. CsA did not affect the growth of MLR-primed CTL in secondary LD culture. Furthermore, CsA slightly inhibited the cytolytic activity of some alloantigen-specific CTL clones. These results are discussed with respect to the clinical use of CsA in transplantation medicine. | lld:pubmed |
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| pubmed-article:3108142 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3108142 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3108142 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3108142 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:3108142 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3108142 | pubmed:month | May | lld:pubmed |
| pubmed-article:3108142 | pubmed:issn | 0019-2805 | lld:pubmed |
| pubmed-article:3108142 | pubmed:author | pubmed-author:WagnerHH | lld:pubmed |
| pubmed-article:3108142 | pubmed:author | pubmed-author:KabelitzDD | lld:pubmed |
| pubmed-article:3108142 | pubmed:author | pubmed-author:KOCHF WFW | lld:pubmed |
| pubmed-article:3108142 | pubmed:author | pubmed-author:ZankerBB | lld:pubmed |
| pubmed-article:3108142 | pubmed:author | pubmed-author:ZankerCC | lld:pubmed |
| pubmed-article:3108142 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3108142 | pubmed:volume | 61 | lld:pubmed |
| pubmed-article:3108142 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3108142 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3108142 | pubmed:pagination | 57-62 | lld:pubmed |
| pubmed-article:3108142 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:3108142 | pubmed:meshHeading | pubmed-meshheading:3108142-... | lld:pubmed |
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| pubmed-article:3108142 | pubmed:meshHeading | pubmed-meshheading:3108142-... | lld:pubmed |
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| pubmed-article:3108142 | pubmed:meshHeading | pubmed-meshheading:3108142-... | lld:pubmed |
| pubmed-article:3108142 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:3108142 | pubmed:articleTitle | Human cytotoxic T lymphocytes. II. Frequency analysis of cyclosporin A-sensitive alloreactive cytotoxic T-lymphocyte precursors. | lld:pubmed |
| pubmed-article:3108142 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3108142 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3108142 | lld:pubmed |
