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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1987-7-17
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pubmed:abstractText |
A limiting dilution (LD) culture system was used to investigate the effect of cyclosporin A (CsA) on the activation and differentiation of human alloreactive cytotoxic T-lymphocyte precursors (CTL-p). CsA reduced in a dose-dependent fashion the frequency of alloantigen-inducible CTL-p. With most normal individuals tested there was a 20- to 50-fold reduction of alloreactive CTL-p frequencies in the presence of 500-1000 ng/ml CsA. Both unseparated T cells and CD8+ T cells were CsA-sensitive under LD culture conditions. Importantly, however, alloreactive CTL-p from two out of 21 normal individuals were found to be largely CsA-resistant. CsA did not affect the growth of MLR-primed CTL in secondary LD culture. Furthermore, CsA slightly inhibited the cytolytic activity of some alloantigen-specific CTL clones. These results are discussed with respect to the clinical use of CsA in transplantation medicine.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3108142-2413529,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3108142-329584,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3108142-3926357,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3108142-3933532,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3108142-6214494,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3108142-6216111,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3108142-6238463,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3108142-6327823,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3108142-6332315,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3108142-6445383,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3108142-6456149,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3108142-6459373,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3108142-6459374,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3108142-6804370,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3108142-6982917,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3108142-6991122,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3108142-7009746
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0019-2805
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
61
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
57-62
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3108142-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:3108142-Antigens, Surface,
pubmed-meshheading:3108142-Cell Differentiation,
pubmed-meshheading:3108142-Cyclosporins,
pubmed-meshheading:3108142-Cytotoxicity, Immunologic,
pubmed-meshheading:3108142-Dose-Response Relationship, Immunologic,
pubmed-meshheading:3108142-Humans,
pubmed-meshheading:3108142-Lymphocyte Activation,
pubmed-meshheading:3108142-T-Lymphocytes, Cytotoxic
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pubmed:year |
1987
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pubmed:articleTitle |
Human cytotoxic T lymphocytes. II. Frequency analysis of cyclosporin A-sensitive alloreactive cytotoxic T-lymphocyte precursors.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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