Linked Life Data

310656

Source:http://linkedlifedata.com/resource/pubmed/id/310656

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1979-3-13
pubmed:abstractText
Although Brucella is a good in vivo inducer of interferon, in vitro infection of murine spleen cells by Brucella suis has not, to the present time, led to in vitro synthesis. In the present work we show that normal spleen cells can however synthetize interferon in vitro when cultured together with adherent cells obtained from the spleens of syngeneic mice 45 min after in vivo inoculation. Induction and synthesis are thus shown to be distinct phenomena. Moreover soluble factors are shown to be involved in the induction phenomenon and T cells to be essential for synthesis. This in vitro brucella-induced interferon differs from in vivo brucella-induced interferon: its acid lability and its antigenic properties are characteristic of type II "immune" interferon.
pubmed:language
fre
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0300-4910
pubmed:author
pubmed:issnType
Print
pubmed:volume
129 C
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
715-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
[Adherent cell and T lymphocyte cooperation for the "in vitro" production of Brucella-induced interferon by murine spleen cells (author's transl)].
pubmed:publicationType
Journal Article, In Vitro, English Abstract