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rdf:type |
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lifeskim:mentions |
umls-concept:C0003232,
umls-concept:C0021311,
umls-concept:C0030705,
umls-concept:C0033809,
umls-concept:C0205210,
umls-concept:C0441655,
umls-concept:C0453882,
umls-concept:C0683598,
umls-concept:C1274040,
umls-concept:C1533691,
umls-concept:C1707455
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|
pubmed:issue |
3
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pubmed:dateCreated |
1987-5-29
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|
pubmed:abstractText |
Techniques for demonstrating synergy in vitro were compared in testing different beta-lactam-aminoglycoside combinations against 30 isolates of Pseudomonas aeruginosa. Poor concordance was noted among the results from chequerboard and 6 h and 24 h time-kill methods. Comparison of in-vitro synergy results with clinical outcome in 14 patients with pseudomonas infection showed that antagonism in the 24 h time-kill method was the most reliable prognostic indicator of clinical and bacteriological outcome. Although more than 70% of patients were cured clinically with cefsulodin or ticarcillin with tobramycin or amikacin, pseudomonas resistant to the beta-lactam emerged in 7 of 14 patients (50%); of those seven, three had poor clinical outcome. The rationale of adding aminoglycoside to beta-lactams against P. aeruginosa to prevent emergence of resistance needs closer examination.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0305-7453
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
19
|
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pubmed:owner |
NLM
|
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pubmed:authorsComplete |
Y
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pubmed:pagination |
321-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:3106305-Adult,
pubmed-meshheading:3106305-Aged,
pubmed-meshheading:3106305-Amikacin,
pubmed-meshheading:3106305-Aminoglycosides,
pubmed-meshheading:3106305-Anti-Bacterial Agents,
pubmed-meshheading:3106305-Cefsulodin,
pubmed-meshheading:3106305-Drug Synergism,
pubmed-meshheading:3106305-Drug Therapy, Combination,
pubmed-meshheading:3106305-Female,
pubmed-meshheading:3106305-Humans,
pubmed-meshheading:3106305-Male,
pubmed-meshheading:3106305-Microbial Sensitivity Tests,
pubmed-meshheading:3106305-Middle Aged,
pubmed-meshheading:3106305-Penicillin Resistance,
pubmed-meshheading:3106305-Pseudomonas Infections,
pubmed-meshheading:3106305-Pseudomonas aeruginosa,
pubmed-meshheading:3106305-Ticarcillin,
pubmed-meshheading:3106305-Tobramycin
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|
pubmed:year |
1987
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|
pubmed:articleTitle |
Comparison of the activity of antibiotic combinations in vitro with clinical outcome and resistance emergence in serious infection by Pseudomonas aeruginosa in non-neutropenic patients.
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pubmed:publicationType |
Journal Article,
Comparative Study
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