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rdf:type |
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|
lifeskim:mentions |
|
|
pubmed:issue |
1
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pubmed:dateCreated |
1987-6-5
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pubmed:abstractText |
Insulin was found to increase protein kinase C activity in BC3H-1 myocytes as determined by in vitro phosphorylation of both a lysine-rich histone fraction (histone III-S) and vinculin. TPA treatment for 20 min or 18 h provoked an apparent loss of histone-directed but not vinculin-directed phosphorylation by cytosolic C-kinase. Thus, chronic TPA-induced 'desensitization' or 'depletion' of cellular protein kinase C is more apparent than real, and is not a valid means for evaluating the role of C-kinase in hormone action.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0014-5793
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
6
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pubmed:volume |
214
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
122-6
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:3106082-Animals,
pubmed-meshheading:3106082-Cells, Cultured,
pubmed-meshheading:3106082-Histones,
pubmed-meshheading:3106082-Insulin,
pubmed-meshheading:3106082-Muscle Proteins,
pubmed-meshheading:3106082-Muscles,
pubmed-meshheading:3106082-Phosphorylation,
pubmed-meshheading:3106082-Protein Kinase C,
pubmed-meshheading:3106082-Tetradecanoylphorbol Acetate,
pubmed-meshheading:3106082-Vinculin
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pubmed:year |
1987
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pubmed:articleTitle |
Insulin but not phorbol ester treatment increases phosphorylation of vinculin by protein kinase C in BC3H-1 myocytes.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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