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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
1987-5-4
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pubmed:abstractText |
Thyrotropin-releasing hormone has been reported to increase strength in patients with amyotrophic lateral sclerosis (ALS). DN-1417 is an analog of thyrotropin-releasing hormone, which has less endocrinologic activity, but more anterior horn cell stimulating effect (with no "autorefractory state"). However, 2 mg DN-1417, IM twice a day for 1 month in an open-label trial, produced no objective improvement of strength in nine patients with ALS. No patient entered the double-blind, placebo-controlled phase of the trial.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0028-3878
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
37
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
715-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:3104820-Adult,
pubmed-meshheading:3104820-Aged,
pubmed-meshheading:3104820-Amyotrophic Lateral Sclerosis,
pubmed-meshheading:3104820-Drug Evaluation,
pubmed-meshheading:3104820-Hormones,
pubmed-meshheading:3104820-Humans,
pubmed-meshheading:3104820-Male,
pubmed-meshheading:3104820-Middle Aged,
pubmed-meshheading:3104820-Muscles,
pubmed-meshheading:3104820-Thyrotropin-Releasing Hormone
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pubmed:year |
1987
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pubmed:articleTitle |
Treatment of amyotrophic lateral sclerosis with the TRH analog DN-1417.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.
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