Linked Life Data

3103861

Source:http://linkedlifedata.com/resource/pubmed/id/3103861

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1987-5-20
pubmed:abstractText
While recent studies indicate that proposed regulation of visual cortex plasticity by norepinephrine (NE) probably involves 6-hydroxydopamine (6-OHDA) effects other than NE depletion, reports of diminished neuronal maturation and reduced postweaning sensitivity to environmental conditions in animals treated with anti-adrenergic compounds continue to suggest a role for NE in neocortical development. To assess its possible role in development of a highly organized neocortical structure, the effects of postnatal 6-OHDA administration upon development of the somatosensory cortical posteromedial barrel subfield (PMBSF), which subserves the large facial whiskers, were observed in mice with whiskers in the middle row of the face removed unilaterally. Treatment with 6-OHDA caused 96-98% depletion of NE in parietal cortex. There were no effects of (or lesion interactions with) 6-OHDA treatment on barrel size in measures of Nissl-stained neurons, and 6-OHDA effects on numerical measures of dendritic branching of Golgi-impregnated non-pyramidal neurons in PMBSF were negligible. There were, however, effects of 6-OHDA treatment upon the highly ordered arrangement of dendrites within barrels. In 6-OHDA-treated animals, the class I (spiny and sparsely spined) cell dendrites were less attracted to the barrel hollow. In controls, for class I cells with their somata within the barrel wall, there was a high correlation between the distance from the soma to the hollow and the amount of dendrite in the wall, reflecting the distance the dendrite traverses to the hollow. In 6-OHDA-treated animals, this correlation was absent, i.e., cells at any distance from the hollow tended to have a high percentage of dendrite in the wall.(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
10
pubmed:volume
403
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
113-20
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Effects of neonatal 6-hydroxydopamine treatment upon morphological organization of the posteromedial barrel subfield in mouse somatosensory cortex.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.