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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1987-4-8
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pubmed:abstractText |
Endothelial cell growth factor (ECGF) is a potent polypeptide mitogen for endothelial cells and fibroblasts. The mitogenic effects of ECGF are inhibited by the lymphokine gamma-interferon (gamma-IFN) in a dose-dependent manner. Gamma-IFN also induces a unique change in endothelial cell morphology which is maximally expressed in the presence of ECGF. The antiproliferative and phenotypic modulatory effects of gamma-IFN on endothelial cells are reversible. Inhibition of ECGF-induced endothelial cell proliferation by gamma-IFN is accompanied by a concentration- and time-dependent decrease in binding of 125I-ECGF to the endothelial cell surface. Scatchard analyses of the binding data in the presence and absence of gamma-IFN demonstrate a decrease in the number of ECGF-binding sites rather than a decrease in ligand affinity for the receptor. Cross-linking experiments with disuccinimidyl suberate demonstrate a decrease in the 170,000 Mr cross-linked receptor-ligand complex. These data suggest that gamma-IFN inhibits endothelial cell proliferation by a mechanism which involves growth factor receptor modulation.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3102503-181786,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3102503-2411423,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3102503-2412230,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/3102503-2421762,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/3102503-3160668,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/3102503-799908
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0021-9525
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
104
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
689-96
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:3102503-Cell Division,
pubmed-meshheading:3102503-Cells, Cultured,
pubmed-meshheading:3102503-Endothelial Growth Factors,
pubmed-meshheading:3102503-Endothelium,
pubmed-meshheading:3102503-Growth Substances,
pubmed-meshheading:3102503-Humans,
pubmed-meshheading:3102503-Interferon-gamma,
pubmed-meshheading:3102503-Kinetics,
pubmed-meshheading:3102503-Receptors, Mitogen,
pubmed-meshheading:3102503-Receptors, Vascular Endothelial Growth Factor,
pubmed-meshheading:3102503-Recombinant Proteins,
pubmed-meshheading:3102503-Umbilical Veins
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pubmed:year |
1987
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pubmed:articleTitle |
Inhibition of endothelial cell proliferation by gamma-interferon.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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