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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1979-2-23
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pubmed:abstractText |
The presence of Ia-like antigens was demonstrated on a small population (2-6%) of highly purified human circulating T lymphocytes by immunofluorescence with a rabbit anti-Ia serum raised against the isolated bimolecular Ia structure. The Ia+ T lymphocytes have no surface or intracellular immunoglobulins. The expansion of this Ia+ T-cell population was encountered in certain patients. Ia antigens were also found on T blasts grown in long-term cultures with conditioned medium generated by phytohemagglutinin-stimulated lymphocytes. In addition, leukemia blasts which stained for Ia antigens and formed E rosettes were identified in the peripheral blood of two leukemic patients. This evidence further supports the existence of Ia-bearing T cells in man. The Ia+ T-lymphocyte population was shown to contain cells responsible for the generation of allogeneic helper activity. Elimination of Ia+ lymphocytes from a purified T-cell population by the anti-Ia antiserum and complement abolished its ability to help an allogeneic B-cell preparation to generate plaque-forming cells against sheep erythrocytes in vitro in the presence of the antigen.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/309915-1083525,
http://linkedlifedata.com/resource/pubmed/commentcorrection/309915-1085338,
http://linkedlifedata.com/resource/pubmed/commentcorrection/309915-1104744,
http://linkedlifedata.com/resource/pubmed/commentcorrection/309915-181845,
http://linkedlifedata.com/resource/pubmed/commentcorrection/309915-270750,
http://linkedlifedata.com/resource/pubmed/commentcorrection/309915-302314,
http://linkedlifedata.com/resource/pubmed/commentcorrection/309915-340589,
http://linkedlifedata.com/resource/pubmed/commentcorrection/309915-4612522,
http://linkedlifedata.com/resource/pubmed/commentcorrection/309915-47890,
http://linkedlifedata.com/resource/pubmed/commentcorrection/309915-62389,
http://linkedlifedata.com/resource/pubmed/commentcorrection/309915-702050,
http://linkedlifedata.com/resource/pubmed/commentcorrection/309915-71738,
http://linkedlifedata.com/resource/pubmed/commentcorrection/309915-778323
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
148
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1423-8
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:309915-Antigens, Surface,
pubmed-meshheading:309915-Cells, Cultured,
pubmed-meshheading:309915-Genetic Linkage,
pubmed-meshheading:309915-HLA Antigens,
pubmed-meshheading:309915-Humans,
pubmed-meshheading:309915-Isoantigens,
pubmed-meshheading:309915-Leukemia,
pubmed-meshheading:309915-Lymphocyte Cooperation,
pubmed-meshheading:309915-Rosette Formation,
pubmed-meshheading:309915-T-Lymphocytes
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pubmed:year |
1978
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pubmed:articleTitle |
Ia-bearing T lymphocytes in man. Their identification and role in the generation of allogeneic helper activity.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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