Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
23
pubmed:dateCreated
1987-1-14
pubmed:abstractText
The differentiation antigen T4, present on the helper/inducer subset of T lymphocytes, is thought to serve as the receptor for the human immunodeficiency virus (HIV). We find that a 60-kDa protein, immunoprecipitable by monoclonal antibody (mAb) OKT4, is present on membranes from human brain as well as human T cells. Furthermore, the radioiodinated HIV envelope glycoprotein [125I-labeled gp120 (125I-gp120)] can be specifically covalently affixed to a molecule present on rat, monkey, and human brain membranes to yield a complex that is indistinguishable from that formed on human T cells. T4 antigen has been studied on unfixed squirrel monkey, rat, and human brain sections by autoradiography using the mAb OKT4. A highly conserved neuroanatomical pattern has been demonstrated, suggesting an analogous organization in these three mammalian brains. Furthermore, the localization of 125I-gp120 receptor binding appears similar to that of T4 and is highly reminiscent of patterns for many previously characterized neuropeptide receptors. A computer-assisted analysis of gp120 suggested that a previously unremarkable octapeptide sequence within the gp120 protein, which we have synthesized and termed "peptide T," may play an important role in HIV attachment. Thus, peptide T and three rationally designed peptide analogs, each with a systematic amino acid substitution, potently inhibit specific 125I-gp120 binding to brain membranes. Additionally, when tested in a viral infectivity assay, these peptides show the same rank order and similar absolute potency to block HIV infection of human T cells. Thus, peptide T may provide a useful pharmacological or immunological basis for the control and treatment of AIDS.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/3097649-16593172, http://linkedlifedata.com/resource/pubmed/commentcorrection/3097649-185626, http://linkedlifedata.com/resource/pubmed/commentcorrection/3097649-2417120, http://linkedlifedata.com/resource/pubmed/commentcorrection/3097649-2578227, http://linkedlifedata.com/resource/pubmed/commentcorrection/3097649-2578615, http://linkedlifedata.com/resource/pubmed/commentcorrection/3097649-2948211, http://linkedlifedata.com/resource/pubmed/commentcorrection/3097649-2981635, http://linkedlifedata.com/resource/pubmed/commentcorrection/3097649-2989371, http://linkedlifedata.com/resource/pubmed/commentcorrection/3097649-2989832, http://linkedlifedata.com/resource/pubmed/commentcorrection/3097649-2995487, http://linkedlifedata.com/resource/pubmed/commentcorrection/3097649-3001528, http://linkedlifedata.com/resource/pubmed/commentcorrection/3097649-4687585, http://linkedlifedata.com/resource/pubmed/commentcorrection/3097649-6083454, http://linkedlifedata.com/resource/pubmed/commentcorrection/3097649-6087149, http://linkedlifedata.com/resource/pubmed/commentcorrection/3097649-6087328, http://linkedlifedata.com/resource/pubmed/commentcorrection/3097649-6089338, http://linkedlifedata.com/resource/pubmed/commentcorrection/3097649-6096719, http://linkedlifedata.com/resource/pubmed/commentcorrection/3097649-6152037, http://linkedlifedata.com/resource/pubmed/commentcorrection/3097649-6232002, http://linkedlifedata.com/resource/pubmed/commentcorrection/3097649-6286904, http://linkedlifedata.com/resource/pubmed/commentcorrection/3097649-6314874, http://linkedlifedata.com/resource/pubmed/commentcorrection/3097649-6320168, http://linkedlifedata.com/resource/pubmed/commentcorrection/3097649-6449704, http://linkedlifedata.com/resource/pubmed/commentcorrection/3097649-6769382, http://linkedlifedata.com/resource/pubmed/commentcorrection/3097649-6972307
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:volume
83
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
9254-8
pubmed:dateRevised
2010-9-10
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Octapeptides deduced from the neuropeptide receptor-like pattern of antigen T4 in brain potently inhibit human immunodeficiency virus receptor binding and T-cell infectivity.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.