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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
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pubmed:dateCreated |
1987-1-21
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pubmed:abstractText |
The in vivo concentration-time profiles of chlorhexidine and noxythiolin bladder irrigations were determined by utilizing high-performance liquid chromatography techniques following a once daily irrigation. A total of 14 chlorhexidine irrigations established a mean concentration of 0.006% w/v, 2-3 h post irrigation. A total of 12 noxythiolin irrigations established a mean concentration of 0.266% w/v, 2-3 h post irrigation, which correlated to a mean formaldehyde concentration of 0.0119% w/v at 2-3 h, as estimated from N-methylthiourea. For both solutions the minimum inhibitory concentration was exceeded for up to 5 h post irrigation, which is sufficient contact time to establish a total kill, thus indicating the possibility that a once daily irrigation may be appropriate in asymptomatic bacteriuria which utilizes either chlorhexidine or noxythiolin.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0143-3180
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
335-42
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:3097078-Aged,
pubmed-meshheading:3097078-Bacteriuria,
pubmed-meshheading:3097078-Chlorhexidine,
pubmed-meshheading:3097078-Chromatography, High Pressure Liquid,
pubmed-meshheading:3097078-Humans,
pubmed-meshheading:3097078-Noxythiolin,
pubmed-meshheading:3097078-Therapeutic Irrigation,
pubmed-meshheading:3097078-Thiourea,
pubmed-meshheading:3097078-Urinary Bladder
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pubmed:year |
1986
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pubmed:articleTitle |
Determination of in vivo concentration-time profiles of chlorhexidine and noxythiolin bladder irrigations.
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pubmed:publicationType |
Journal Article
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