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rdf:type |
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lifeskim:mentions |
umls-concept:C0021469,
umls-concept:C0024109,
umls-concept:C0032172,
umls-concept:C0033554,
umls-concept:C0040061,
umls-concept:C0085979,
umls-concept:C0106751,
umls-concept:C0205314,
umls-concept:C0231491,
umls-concept:C0679622,
umls-concept:C1280500,
umls-concept:C1522492
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pubmed:dateCreated |
1986-12-10
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pubmed:abstractText |
The effects of a new Platelet-Activating Factor (PAF-acether) antagonist (BN 52021) extracted from Ginkgo biloba leaves have been studied on the release of metabolites of arachidonic acid in IgG-dependent guinea pig pulmonary anaphylaxis in vitro. Prostaglandin E2 (PGE2) and thromboxane B2 (TxB2) were assayed using a novel ELISA technique. The release of PGE2 and TxB2 from anaphylactic lungs reached a maximum 4-5 min following the antigen challenge (about 3.2 and 31.0 ng/ml respectively) and decayed slowly during the following 25 min. BN 52021 (1, 3 and 30 micrograms/ml) produced dose-dependent decreases of the release of PGE2 and TxB2. These results suggest that there are some interactions between the release of icosanoids and PAF-acether in anaphylaxis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Arachidonic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Arachidonic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Dinoprostone,
http://linkedlifedata.com/resource/pubmed/chemical/Diterpenes,
http://linkedlifedata.com/resource/pubmed/chemical/Ginkgolides,
http://linkedlifedata.com/resource/pubmed/chemical/Lactones,
http://linkedlifedata.com/resource/pubmed/chemical/Ovalbumin,
http://linkedlifedata.com/resource/pubmed/chemical/Plant Extracts,
http://linkedlifedata.com/resource/pubmed/chemical/Platelet Activating Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Prostaglandins,
http://linkedlifedata.com/resource/pubmed/chemical/Prostaglandins E,
http://linkedlifedata.com/resource/pubmed/chemical/Thromboxane B2,
http://linkedlifedata.com/resource/pubmed/chemical/Thromboxanes,
http://linkedlifedata.com/resource/pubmed/chemical/ginkgolide B
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0031-6989
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
18 Suppl
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
111-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:3095849-Anaphylaxis,
pubmed-meshheading:3095849-Animals,
pubmed-meshheading:3095849-Arachidonic Acid,
pubmed-meshheading:3095849-Arachidonic Acids,
pubmed-meshheading:3095849-Dinoprostone,
pubmed-meshheading:3095849-Diterpenes,
pubmed-meshheading:3095849-Female,
pubmed-meshheading:3095849-Ginkgolides,
pubmed-meshheading:3095849-Guinea Pigs,
pubmed-meshheading:3095849-Kinetics,
pubmed-meshheading:3095849-Lactones,
pubmed-meshheading:3095849-Lung,
pubmed-meshheading:3095849-Male,
pubmed-meshheading:3095849-Ovalbumin,
pubmed-meshheading:3095849-Plant Extracts,
pubmed-meshheading:3095849-Platelet Activating Factor,
pubmed-meshheading:3095849-Prostaglandins,
pubmed-meshheading:3095849-Prostaglandins E,
pubmed-meshheading:3095849-Thromboxane B2,
pubmed-meshheading:3095849-Thromboxanes
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pubmed:year |
1986
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pubmed:articleTitle |
Inhibitory effects of a novel platelet activating factor (PAF) antagonist (BN 52021) on antigen-induced prostaglandin and thromboxane formation by the guinea pig lung.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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