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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
9
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pubmed:dateCreated |
1986-11-7
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pubmed:abstractText |
Nicardipine, a new calcium channel blocking drug of the dihydropyridine family, was administered to 63 patients at a dose of 30 or 40 mg 3 times daily in a multicenter, randomized, double-blind, placebo-controlled, crossover trial. Nicardipine midly increased heart rate (HR) at rest and midly decreased the blood pressure (BP) at rest. When generally similar responses to the 30- and 40-mg doses were averaged, nicardipine produced a 7% increase in peak exercise HR, which was balanced by a 6% decrease in peak exercise BP. Thus, no change occurred in the exercise HR-BP product. With nicardipine, treadmill exercise duration increased 9%, time to angina increased 15%, time to 1-mm ST-segment depression increased 16%, and oxygen consumption at peak exercise increased 13%. Mean anginal frequency declined, as did mean weekly sublingual nitroglycerin consumption, but not significantly. There were more cardiovascular side effects with nicardipine than with placebo, with at least 3 patients having increased angina judged by investigators as probably related to the drug. Vasodilatory side effects were also more frequent with nicardipine, but were generally mild and well tolerated; the drug had to be discontinued in only 1 patient, because of vasodilatory effects. Nicardipine is effective and generally well tolerated in patients with chronic stable angina.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0002-9149
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:day |
1
|
pubmed:volume |
58
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
715-21
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:3094355-Adult,
pubmed-meshheading:3094355-Aged,
pubmed-meshheading:3094355-Angina Pectoris,
pubmed-meshheading:3094355-Clinical Trials as Topic,
pubmed-meshheading:3094355-Double-Blind Method,
pubmed-meshheading:3094355-Female,
pubmed-meshheading:3094355-Humans,
pubmed-meshheading:3094355-Male,
pubmed-meshheading:3094355-Middle Aged,
pubmed-meshheading:3094355-Nicardipine,
pubmed-meshheading:3094355-Nitroglycerin,
pubmed-meshheading:3094355-Random Allocation
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pubmed:year |
1986
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pubmed:articleTitle |
Efficacy and safety of nicardipine for chronic, stable angina pectoris: a multicenter randomized trial.
|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial
|