Linked Life Data

3092991

Source:http://linkedlifedata.com/resource/pubmed/id/3092991

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1986-11-20
pubmed:abstractText
Cell suspensions of embryonic brainstem containing the locus coeruleus were injected intervertebrally into the lumbar spinal cord of adult rats whose descending catecholamine (CA) fibers had been lesioned with intracisternal injection of 6-hydroxydopamine. Up to 1100 CA cells were found 2 and 4 months later, and these cells grew processes which produced histologically detectable reinnervation of the lumbar gray matter on the injected side of the cord. To assess the functional activity of the transplanted CA cells, the force of the hindlimb flexion reflex was measured in acute spinal rats. This reflex has been shown previously to be strongly enhanced by catecholamines. The flexion reflexes were significantly stronger in the transplanted rats than in the controls. Further, the flexion reflexes were significantly reduced by phenoxybenzamine, an alpha-adrenergic blocker, in the transplanted rats while the reflexes of controls were not significantly changed. These results demonstrate that cell suspension transplants of embryonic brainstem containing the locus coeruleus into the adult rat spinal cord survive, grow reinnervating catecholamine processes, and can affect the functional activity of the spinal cord.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
3
pubmed:volume
381
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
225-36
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Transplants of embryonic brainstem containing the locus coeruleus into spinal cord enhance the hindlimb flexion reflex in adult rats.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't