rdf:type |
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lifeskim:mentions |
umls-concept:C0004499,
umls-concept:C0015309,
umls-concept:C0020852,
umls-concept:C0026809,
umls-concept:C0033809,
umls-concept:C0040341,
umls-concept:C0087111,
umls-concept:C0243026,
umls-concept:C0279023,
umls-concept:C0314768,
umls-concept:C1446680,
umls-concept:C1515655
|
pubmed:dateCreated |
1986-10-16
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pubmed:abstractText |
Mice with cyclophosphamide-induced neutropenia were challenged with four immunotypes of Pseudomonas aeruginosa by contamination of a small dorsal surface wound. The infections were lethal; 100% of control animals (n = 80) treated only with albumin died. Administration of an immunoglobulin G intravenous preparation (IGIV) and/or therapy with tobramycin or azlocillin was begun 16 hr after challenge. Mortality among mice (n = 120) treated only with an antibiotic was 75.0%, while that among mice (n = 80) treated only with IGIV was 78.8%. Combination therapy with IGIV and an antibiotic (n = 120) resulted in mortality of 38.3%. The protection afforded by IGIV may have resulted in part from neutralization of exotoxin A, as mice treated with IGIV before challenge with exotoxin A were subject to lower mortality and had lower levels of serum aspartate and alanine aminotransferases than controls.
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ADP Ribose Transferases,
http://linkedlifedata.com/resource/pubmed/chemical/Azlocillin,
http://linkedlifedata.com/resource/pubmed/chemical/Bacterial Toxins,
http://linkedlifedata.com/resource/pubmed/chemical/Exotoxins,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulins, Intravenous,
http://linkedlifedata.com/resource/pubmed/chemical/Tobramycin,
http://linkedlifedata.com/resource/pubmed/chemical/Virulence Factors,
http://linkedlifedata.com/resource/pubmed/chemical/toxA protein, Pseudomonas aeruginosa
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pubmed:status |
MEDLINE
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pubmed:issn |
0162-0886
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pubmed:author |
|
pubmed:issnType |
Print
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pubmed:volume |
8 Suppl 4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
S420-5
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pubmed:dateRevised |
2004-4-8
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pubmed:meshHeading |
pubmed-meshheading:3092309-ADP Ribose Transferases,
pubmed-meshheading:3092309-Animals,
pubmed-meshheading:3092309-Azlocillin,
pubmed-meshheading:3092309-Bacterial Toxins,
pubmed-meshheading:3092309-Combined Modality Therapy,
pubmed-meshheading:3092309-Drug Synergism,
pubmed-meshheading:3092309-Exotoxins,
pubmed-meshheading:3092309-Female,
pubmed-meshheading:3092309-Immunoglobulin G,
pubmed-meshheading:3092309-Immunoglobulins, Intravenous,
pubmed-meshheading:3092309-Mice,
pubmed-meshheading:3092309-Neutropenia,
pubmed-meshheading:3092309-Pseudomonas Infections,
pubmed-meshheading:3092309-Tobramycin,
pubmed-meshheading:3092309-Virulence Factors
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pubmed:articleTitle |
Immunoglobulin G: potentiation of tobramycin and azlocillin in the treatment of Pseudomonas aeruginosa sepsis in neutropenic mice and neutralization of exotoxin A in vivo.
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pubmed:publicationType |
Journal Article
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