Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
18
pubmed:dateCreated
1986-10-22
pubmed:abstractText
We have developed a simple, objectively scorable test for the mutagenicity of chemical compounds which can be fed Drosophila melanogaster. The test depends upon the somatic reversion of the X chromosome, recessive eye color mutation, white-ivory (wi) to wild type (w+). Reversions are scored as clones of w+ facets in the wi eyes of eclosing adults. To increase the sensitivity, a tandem quadruplication containing four wi mutations was synthesized. Thus, in homozygous females eight wi mutations are potentially revertible. Six mutagenic compounds, all alkylating agents, all gave positive results at several concentrations tested. Molecular analysis demonstrates that the induced reversions, germinal and somatic, are associated with the loss of 2.9-kilobase DNA duplicated in the wi mutation.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/3092217-1055375, http://linkedlifedata.com/resource/pubmed/commentcorrection/3092217-1061098, http://linkedlifedata.com/resource/pubmed/commentcorrection/3092217-1195397, http://linkedlifedata.com/resource/pubmed/commentcorrection/3092217-13139456, http://linkedlifedata.com/resource/pubmed/commentcorrection/3092217-16593607, http://linkedlifedata.com/resource/pubmed/commentcorrection/3092217-2990728, http://linkedlifedata.com/resource/pubmed/commentcorrection/3092217-5807334, http://linkedlifedata.com/resource/pubmed/commentcorrection/3092217-5884226, http://linkedlifedata.com/resource/pubmed/commentcorrection/3092217-5939573, http://linkedlifedata.com/resource/pubmed/commentcorrection/3092217-6281775, http://linkedlifedata.com/resource/pubmed/commentcorrection/3092217-6290082, http://linkedlifedata.com/resource/pubmed/commentcorrection/3092217-6341825
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:volume
83
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
6667-71
pubmed:dateRevised
2010-9-9
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Genetic-molecular basis for a simple Drosophila melanogaster somatic system that detects environmental mutagens.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't