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pubmed-article:3091861rdf:typepubmed:Citationlld:pubmed
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pubmed-article:3091861pubmed:issue4lld:pubmed
pubmed-article:3091861pubmed:dateCreated1986-10-1lld:pubmed
pubmed-article:3091861pubmed:abstractTextTo evaluate the temporal pattern of urea excretion in chair-adapted primates (Macaque fascicularis) on continuous total parenteral nutrition (TPN), two groups of five animals were studied. Group I received continuous TPN (75 glucose kcal; 0.56 g nitrogen; and 100 ml fluid per kg per day) while Group II received a single morning isonitrogenous oral meal along with a continuous isovolemic intravenous infusion of 0.45% saline. Urine was collected hourly in group I for 2 days and every 4 hr in group II for 5 days and analyzed for urea content. Time series analysis revealed no periodicity of urea excretion in either group. Six animals were then studied for a total of 46 TPN days to define the relationship between the urea content of a single 3-hr morning urine aliquot and its respective content in a 24-hr collection. A significant linear relationship was found (r = +0.76, p less than 0.01). However, using this relationship, a reasonable estimate (+20%) of measured 24-hr urea output was achieved only 50% of the time using a single 3-hr urea output. Chair-adapted primates maintained on continuous TPN or a single oral meal with continuous saline infusion do not exhibit a periodic pattern of urea excretion. The variability in 3-hr urinary urea output in the chaired primate on continuous TPN does not consistently permit accurate estimation of the coincident 24-hr urinary urea output.lld:pubmed
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pubmed-article:3091861pubmed:statusMEDLINElld:pubmed
pubmed-article:3091861pubmed:issn0148-6071lld:pubmed
pubmed-article:3091861pubmed:authorpubmed-author:MullerJ HJHlld:pubmed
pubmed-article:3091861pubmed:authorpubmed-author:DempseyD TDTlld:pubmed
pubmed-article:3091861pubmed:authorpubmed-author:MelnikGGlld:pubmed
pubmed-article:3091861pubmed:authorpubmed-author:NgaiY LYLlld:pubmed
pubmed-article:3091861pubmed:authorpubmed-author:CrosbyL OLOlld:pubmed
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pubmed-article:3091861pubmed:volume10lld:pubmed
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pubmed-article:3091861pubmed:pagination369-74lld:pubmed
pubmed-article:3091861pubmed:dateRevised2007-2-21lld:pubmed
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pubmed-article:3091861pubmed:articleTitleUrea nitrogen excretion in chair-adapted primates.lld:pubmed
pubmed-article:3091861pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:3091861pubmed:publicationTypeResearch Support, U.S. Gov't, Non-P.H.S.lld:pubmed
pubmed-article:3091861pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed