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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1986-10-15
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pubmed:abstractText |
Purified rRNA from Listeria monocytogenes or Pseudomonas aeruginosa injected in combination with dimethyldioctadecylammonium bromide (DDA), protects mice nonspecifically against a lethal challenge of various extra- and intracellular bacteria. In the present study vaccination of BALB/c as well as C57BL/Ka mice with listerial RNA-DDA resulted in activation of fixed-tissue macrophages, as measured by an enhanced in vivo L. monocytogenes killing in spleen and liver. Evidence was found that macrophage activation by vaccination with rRNA-DDA occurred by a T-cell-independent mechanism. Treatment of mice with cyclosporin A had no effect on the enhanced L. monocytogenes killing induced with RNA-DDA; in vitro exposure of RNA-DDA to spleen cell cultures did not give rise to any lymphocyte proliferation. No evidence could be found for a possible adjuvant activity for RNA-DDA in cellular responses; in fact, RNA-DDA had an inhibitory effect on lymphocyte proliferative responses to Listeria antigen and to concanavalin A.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3091505-14293000,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3091505-2412492,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3091505-30697,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3091505-403135,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3091505-412787,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3091505-417029,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3091505-4215743,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3091505-4957610,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3091505-6084981,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3091505-6153637,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3091505-6154645,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3091505-6166565,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3091505-6167518,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3091505-6406074,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3091505-6407112,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3091505-6411853,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3091505-6421982,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3091505-6434908,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3091505-6602835,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3091505-6766161,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3091505-6792287,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3091505-6805064,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3091505-6807832,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3091505-6872317,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3091505-805175,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3091505-806463,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3091505-807647
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0019-9567
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
53
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
611-5
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3091505-Adjuvants, Immunologic,
pubmed-meshheading:3091505-Animals,
pubmed-meshheading:3091505-Cyclosporins,
pubmed-meshheading:3091505-Female,
pubmed-meshheading:3091505-Listeria monocytogenes,
pubmed-meshheading:3091505-Liver,
pubmed-meshheading:3091505-Lymphocyte Activation,
pubmed-meshheading:3091505-Macrophage Activation,
pubmed-meshheading:3091505-Male,
pubmed-meshheading:3091505-Mice,
pubmed-meshheading:3091505-Mice, Inbred BALB C,
pubmed-meshheading:3091505-Mice, Inbred C57BL,
pubmed-meshheading:3091505-Quaternary Ammonium Compounds,
pubmed-meshheading:3091505-RNA, Ribosomal,
pubmed-meshheading:3091505-Spleen,
pubmed-meshheading:3091505-T-Lymphocytes,
pubmed-meshheading:3091505-Vaccination
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pubmed:year |
1986
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pubmed:articleTitle |
T-cell-independent macrophage activation in mice induced with rRNA from Listeria monocytogenes and dimethyldioctadecylammonium bromide.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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