Linked Life Data

3090903

Source:http://linkedlifedata.com/resource/pubmed/id/3090903

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1986-9-25
pubmed:abstractText
The kidneys of 15 human foetuses (10-18 weeks of age) were used for morphometric studies on peroxisomes during gestational development and in organ culture. The catalase positive organelles revealed by DAB were round to ovoid with a granular matrix delimited by a membrane occasionally deformed by marginal plates. Generally, the distribution was uniform in cells of proximal tubules. In the same cell, size and density varied. The number fluctuated from cell to cell. No significant difference in the mean diameter was observed from the 10th to 18th weeks of gestation, although the mean value (0.36 +/- 0.1 micron) was significantly less than the adult figure. These results indicate that size modifications might occur later on in gestation or after birth to reach the adult value. During the studied period, the mean number of peroxisomes per 100 micron2 of surface area did not differ significantly from that of the 10-12 week group (10.5 +/- 1.97). No important changes of peroxisome morphology in kidney explants cultured for 7 days were noticed on day 3-4. Thereafter, the shape of many peroxisomes became elongated or irregular; marginal plates were frequent. A decrease in the diameter of peroxisomes began at day 4, became significant on day 5 and more accentuated on day 7. In addition, as the culture matured, there was a progressive reduction in catalase activity, revealed by a diminished density of the peroxisomal matrix. The number of DAB positive organelles per surface area decreased steadily with culture age, and significantly on day 2 (p less than 0.01) to become drastically low on day 5 and negligible on day 7.(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0340-2061
pubmed:author
pubmed:issnType
Print
pubmed:volume
174
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
235-42
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Peroxisomes in human foetal kidney: variations in size and number during development.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't