| pubmed-article:3089936 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3089936 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:3089936 | lifeskim:mentions | umls-concept:C0008150 | lld:lifeskim |
| pubmed-article:3089936 | lifeskim:mentions | umls-concept:C0178719 | lld:lifeskim |
| pubmed-article:3089936 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:3089936 | lifeskim:mentions | umls-concept:C0598312 | lld:lifeskim |
| pubmed-article:3089936 | lifeskim:mentions | umls-concept:C1156673 | lld:lifeskim |
| pubmed-article:3089936 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:3089936 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:3089936 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:3089936 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:3089936 | pubmed:dateCreated | 1986-9-17 | lld:pubmed |
| pubmed-article:3089936 | pubmed:abstractText | Human uroepithelial (T24) cells were incubated for 24 h in the presence of various concentrations of human recombinant gamma interferon (Hu-rIFN-gamma) and then infected with the 6BC strain of Chlamydia psittaci. This resulted in a reduction of intracellular chlamydial inclusion development in proportion to the concentration of Hu-rIFN-gamma present when Giemsa-stained cells were examined by light microscopy 24 h after infection. When tryptophan was added to Hu-rIFN-gamma-treated cells just after infection, reversal of the Hu-rIFN-gamma-mediated inhibition occurred in proportion to the concentration of tryptophan added. Addition of either isoleucine or lysine did not result in reversal of the antichlamydial state. Transport of L-[3H]tryptophan into acid-soluble intracellular pools was found to be greatly enhanced in Hu-rIFN-gamma-treated T24 cells compared with the rates measured for untreated cells. Transport of [3H]leucine was not increased in treated cells. Cells treated with Hu-rIFN-gamma also degraded L-[3H]tryptophan to catabolites that cochromatographed with N-formylkynurenine and kynurenine as measured by high-performance liquid chromatography. We conclude that Hu-rIFN-gamma-mediated inhibition of intracellular C. psittaci replication in T24 cells occurs by depletion of the essential amino acid tryptophan, most likely via the induction of indoleamine-2,3-dioxygenase, the initial enzyme of tryptophan catabolism. | lld:pubmed |
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| pubmed-article:3089936 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:3089936 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:3089936 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3089936 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:3089936 | pubmed:issn | 0019-9567 | lld:pubmed |
| pubmed-article:3089936 | pubmed:author | pubmed-author:ByrneG IGI | lld:pubmed |
| pubmed-article:3089936 | pubmed:author | pubmed-author:LehmannL KLK | lld:pubmed |
| pubmed-article:3089936 | pubmed:author | pubmed-author:LandryG JGJ | lld:pubmed |
| pubmed-article:3089936 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3089936 | pubmed:volume | 53 | lld:pubmed |
| pubmed-article:3089936 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3089936 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3089936 | pubmed:pagination | 347-51 | lld:pubmed |
| pubmed-article:3089936 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:3089936 | pubmed:year | 1986 | lld:pubmed |
| pubmed-article:3089936 | pubmed:articleTitle | Induction of tryptophan catabolism is the mechanism for gamma-interferon-mediated inhibition of intracellular Chlamydia psittaci replication in T24 cells. | lld:pubmed |
| pubmed-article:3089936 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3089936 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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