Linked Life Data

3088690

Source:http://linkedlifedata.com/resource/pubmed/id/3088690

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2B
pubmed:dateCreated
1986-8-21
pubmed:abstractText
Phospholipase A2 and arachidonic acid mimic the stimulatory effect of prolactin on casein exocytosis. We suggest that prolactin by activating phospholipase A2, induces a release of arachidonic acid which is metabolized by a cyclooxygenase pathway leading to prostaglandins, prostacyclins and thromboxanes, a lipoxygenase pathway leading to hydroperoxides and leukotrienes and an epoxygenase pathway. The effects of prolactin and of the major products of arachidonic acid metabolism were studied by incubating mammary gland fragments of lactating rabbit and by measuring neosynthesized caseins and prostaglandins F (PGF2 alpha) in the incubation medium. Aspirin (10(-3) M) which strongly decreases PGF2 alpha synthesis did not modify exocytosis or prolactin stimulation of exocytosis. However, in some cases where prolactin did not stimulate exocytosis, aspirin could restore this stimulation. Nor-dihydroguaiaretic acid (10 microM), an inhibitor of lipoxygenases, increased PGF2 alpha synthesis in the presence of prolactin. In parallel, this inhibitor increased casein exocytosis but inhibited prolactin stimulation. These results are consistent with the action of arachidonic acid metabolites in the regulation of casein exocytosis. We suggest a dual control by the metabolites of the lipoxygenase and the cyclooxygenase pathways.
pubmed:language
fre
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0181-1916
pubmed:author
pubmed:issnType
Print
pubmed:volume
26
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
575-82
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
[Effect of aspirin and nordihydroguaiaretic acid on the secretion of milk caseins by the mammary epithelial cell].
pubmed:publicationType
Journal Article, English Abstract