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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
|
pubmed:dateCreated |
1986-8-5
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pubmed:abstractText |
This historically controlled study evaluates radiation therapy in 119 patients--with squamous cell carcinomas of the head and neck--who underwent surgery alone (SA) or surgery plus radiation (S + R). The primary tumor control and nodal control, in patients with negative surgical margins who had surgery alone (SA), were 63% in the oral cavity, 60% in the oropharynx, and 67% in the hypopharynx. The same rates for S + R group and negative surgical margins were 100%, 73%, and 100%. Combining the patients with negative and positive surgical margins, control of the tumor and nodal control were the same in the oral cavity for both treatment groups (41% for SA and 44% for S + R) and increased with the addition of radiation in the oropharynx (30% for SA to 65% for S + R) and hypopharynx (33% for SA to 86% for S + R), in spite of higher percentages of T3 and T4 tumor and positive lymph nodes in the S + R group. The lower control rate in patients who had surgery alone could be due (in part) to inadequate surgery at the primary site (42% local excision) and lack of neck dissection (35% for SA vs. 77% for S + R). Postoperative radiation therapy to the primary site and neck is shown to effectively reduce local recurrence in patients with oral cavity and oropharynx cancer, regardless of surgical margins.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
|
pubmed:issn |
0194-5998
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
94
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
601-4
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:3088523-Carcinoma, Squamous Cell,
pubmed-meshheading:3088523-Clinical Trials as Topic,
pubmed-meshheading:3088523-Combined Modality Therapy,
pubmed-meshheading:3088523-Humans,
pubmed-meshheading:3088523-Hypopharyngeal Neoplasms,
pubmed-meshheading:3088523-Lymphatic Metastasis,
pubmed-meshheading:3088523-Mouth Neoplasms,
pubmed-meshheading:3088523-Neck Dissection,
pubmed-meshheading:3088523-Neoplasm Recurrence, Local,
pubmed-meshheading:3088523-Oropharyngeal Neoplasms,
pubmed-meshheading:3088523-Pharyngeal Neoplasms,
pubmed-meshheading:3088523-Postoperative Care
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pubmed:year |
1986
|
pubmed:articleTitle |
Value of radiation therapy in addition to surgery for cancer of the head and neck.
|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study
|