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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1986-8-1
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pubmed:abstractText |
Normal human PBMC were analyzed for the presence of cells expressing both T3 and NKH1 antigens, using direct two-color immunofluorescence. In six individuals, NKH1+T3+ cells were found to represent 2.5% of PBMC and 24% of the total number of NKH1+ cells. Purified NKH1+T3+ cells were shown to have the typical morphology of large granular lymphocytes (LGL). NKH1+T3+ cells also exhibited spontaneous cytotoxicity against K562 target cells and this lytic activity could be inhibited by anti-T3 mAb. Similar results were obtained with NKH1+T3+ cells cultured in vitro in lymphocyte-conditioned medium. Taken together, these results indicate that NKH1+T3+ cells represent a unique population of NK-active cells in normal peripheral blood. Although these cells exhibit LGL morphology and NK activity, this appears to be mediated through a functional T cell-like receptor for target antigen.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
164
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
351-6
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3088199-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:3088199-Antigens, Surface,
pubmed-meshheading:3088199-Cell Differentiation,
pubmed-meshheading:3088199-Cell Separation,
pubmed-meshheading:3088199-Cytotoxicity, Immunologic,
pubmed-meshheading:3088199-Fluorescent Antibody Technique,
pubmed-meshheading:3088199-Humans,
pubmed-meshheading:3088199-Killer Cells, Natural,
pubmed-meshheading:3088199-Phenotype,
pubmed-meshheading:3088199-T-Lymphocytes
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pubmed:year |
1986
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pubmed:articleTitle |
A subset of natural killer cells in peripheral blood displays a mature T cell phenotype.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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