Linked Life Data

3087305

Source:http://linkedlifedata.com/resource/pubmed/id/3087305

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1986-7-15
pubmed:abstractText
3-Isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine (KC-404) caused a potent and concentration-dependent relaxation in isolated canine basilar artery precontracted with prostaglandin (PG) F2 alpha attended by EC50 of 7.6 X 10(-8) g/ml. The relaxing action of KC-404 was little affected by the removal of vascular endothelium, whereas it was significantly diminished by pretreatment with indomethacin (10(-5) M) or acetylsalicylic acid (ASA) (10(-3) M). In PGF2 alpha-contracted canine basilar artery, KC-404-induced relaxation was markedly reversed to contraction by the subsequent addition of indomethacin (10(-5) M), ASA (10(-3) M) and phenidone (10(-4) M) by about 80%, 75% and 111%, respectively, whereas it was little affected by nordihydroguaiaretic acid (NDGA) (10(-5) M). Similar results were obtained when dipyridamole was used as a relaxant but, in contrast, papaverine-induced relaxation was little affected by indomethacin. KC-404 as well as PGI2 showed less potent or no relaxation in both PGF2 alpha-contracted rabbit aorta and KCl-contracted canine basilar artery as compared with PGF2 alpha-contracted canine basilar artery. In PGF2 alpha-contracted canine basilar artery, PGI2-induced relaxation was significantly augmented by pretreatment with KC-404 (10(-8) and 10(-7) g/ml). These results suggest that KC-404 might elicit cerebral vasorelaxation not dependent on vascular endothelium but remarkably dependent on a vasodilating cyclooxygenase metabolite, possibly PGI2.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0301-4533
pubmed:author
pubmed:issnType
Print
pubmed:volume
280
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
216-29
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Mode of cerebral vasodilating action of KC-404 in isolated canine basilar artery.
pubmed:publicationType
Journal Article, In Vitro