| pubmed-article:3086313 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3086313 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:3086313 | lifeskim:mentions | umls-concept:C0042071 | lld:lifeskim |
| pubmed-article:3086313 | lifeskim:mentions | umls-concept:C0016057 | lld:lifeskim |
| pubmed-article:3086313 | lifeskim:mentions | umls-concept:C0699040 | lld:lifeskim |
| pubmed-article:3086313 | lifeskim:mentions | umls-concept:C0014436 | lld:lifeskim |
| pubmed-article:3086313 | lifeskim:mentions | umls-concept:C0032145 | lld:lifeskim |
| pubmed-article:3086313 | pubmed:issue | 17 | lld:pubmed |
| pubmed-article:3086313 | pubmed:dateCreated | 1986-7-9 | lld:pubmed |
| pubmed-article:3086313 | pubmed:abstractText | An approximately 75% pure form of a human Mr approximately 54,000 plasminogen activator inhibitor from conditioned culture fluid of the fibrosarcoma cell line HT-1080 was obtained by a single step of chromatography on concanavalin A-Sepharose. The inhibitor inhibited human urokinase-type plasminogen activator (u-PA) and tissue-type plasminogen activator, but not plasmin. Rabbit antibodies against this plasminogen activator inhibitor also reacted with a plasminogen activator inhibitor with identical electrophoretic mobility in extracts of human blood platelets, indicating that the HT-1080-inhibitor is of the same type as the inhibitor of blood platelets. As revealed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis followed by fibrin-agarose zymography, incubation of HT-1080-inhibitor with the active form of human u-PA led to the formation of an equimolar sodium dodecyl sulfate-resistant complex between them; in contrast, no complex formation was observed between the inhibitor and the proenzyme form of human u-PA (pro-u-PA). Likewise, using a column of anti-inhibitor antibodies coupled to Sepharose for removal of excess inhibitor and activator-inhibitor complexes, the potential enzymatic activity of pro-u-PA was found to be unaffected by incubation with inhibitor under conditions in which more than 95% of the active u-PA had formed complex with inhibitor. | lld:pubmed |
| pubmed-article:3086313 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3086313 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3086313 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:3086313 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3086313 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:3086313 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:3086313 | pubmed:author | pubmed-author:NielsenL SLS | lld:pubmed |
| pubmed-article:3086313 | pubmed:author | pubmed-author:KristensenPP | lld:pubmed |
| pubmed-article:3086313 | pubmed:author | pubmed-author:SkriverLL | lld:pubmed |
| pubmed-article:3086313 | pubmed:author | pubmed-author:AndreasenP... | lld:pubmed |
| pubmed-article:3086313 | pubmed:author | pubmed-author:DanøKK | lld:pubmed |
| pubmed-article:3086313 | pubmed:author | pubmed-author:Grøndahl-Hans... | lld:pubmed |
| pubmed-article:3086313 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3086313 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:3086313 | pubmed:volume | 261 | lld:pubmed |
| pubmed-article:3086313 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3086313 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3086313 | pubmed:pagination | 7644-51 | lld:pubmed |
| pubmed-article:3086313 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:3086313 | pubmed:year | 1986 | lld:pubmed |
| pubmed-article:3086313 | pubmed:articleTitle | Plasminogen activator inhibitor from human fibrosarcoma cells binds urokinase-type plasminogen activator, but not its proenzyme. | lld:pubmed |
| pubmed-article:3086313 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3086313 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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