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PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1986-7-24
pubmed:abstractText
A murine model of peritonitis allowing detection and quantification of in-vivo acquired resistance during short term therapy has been used in order to evaluate the capacity of antimicrobial combinations to limit emergence of resistance, as compared to individual components of the regimens. Mice were challenged intraperitoneally with 10(8) cfu of bacteria. Two hours later, a single antibiotic dose was injected subcutaneously: amikacin (15 mg/kg), ceftriaxone (50 mg/kg), pefloxacin (25 mg/kg), amikacin + ceftriaxone, amikacin + pefloxacin or ceftriaxone + pefloxacin. Escherichia coli and Staphylococcus aureus never became resistant. Single drug therapy yielded resistant mutants in Enterobacter cloacae, Serratia marcescens, Klebsiella pneumoniae and Pseudomonas aeruginosa as follows: 74% of ceftriaxone-treated animals, 57% of pefloxacin treated animals and 27% of amikacin treated animals. All the tested combinations reduced the frequency of in-vivo acquired resistance produced by single drugs, and no combination selected resistance when the separate agents of the combination did not. Combining antimicrobial agents limits the risk of emergence of resistance during antibiotic therapy.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0305-7453
pubmed:author
pubmed:issnType
Print
pubmed:volume
17 Suppl A
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
11-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:3086276-Amikacin, pubmed-meshheading:3086276-Animals, pubmed-meshheading:3086276-Bacteria, pubmed-meshheading:3086276-Bacterial Infections, pubmed-meshheading:3086276-Ceftriaxone, pubmed-meshheading:3086276-Drug Resistance, Microbial, pubmed-meshheading:3086276-Drug Therapy, Combination, pubmed-meshheading:3086276-Enterobacter, pubmed-meshheading:3086276-Escherichia coli, pubmed-meshheading:3086276-Female, pubmed-meshheading:3086276-Kanamycin, pubmed-meshheading:3086276-Klebsiella pneumoniae, pubmed-meshheading:3086276-Mice, pubmed-meshheading:3086276-Norfloxacin, pubmed-meshheading:3086276-Pefloxacin, pubmed-meshheading:3086276-Peritonitis, pubmed-meshheading:3086276-Pseudomonas aeruginosa, pubmed-meshheading:3086276-Serratia marcescens, pubmed-meshheading:3086276-Staphylococcus aureus
pubmed:year
1986
pubmed:articleTitle
Emergence of resistance after therapy with antibiotics used alone or combined in a murine model.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't